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首页 > 医学词汇大全 > Hirsutism
Hirsutism

内分泌

关键词内分泌 疾病 内分泌腺体分泌失衡

词汇介绍

拓展阅读

解析

Hirsutism   英 /'hɜːsjuːtɪz(ə)m/   美 /'hɝsʊ,tɪzəm/

释    义   n. 多毛症(尤指妇女多毛症)

例    句   Most medications used to treat hirsutism are approved by the Food and Drug Administration, but not for this specific indication. 治疗多毛症的多数药物经食物和药物管理局批准,但不是以这专业为指征。

概述

多毛症是指男性和女性在身体不应出现过多毛发的地方出现过多的体毛,尤其是在青春期后发育良好的情况下。多毛症通常可能是肾上腺、卵巢或中枢等内分泌腺体分泌失衡的结果,可能是由于雄激素水平升高所致。头发的数量和位置一般通过Ferriman-Gallwey分数来衡量,它与过度毛发症不同,后者是身体上任何地方的过度毛发生长。治疗方法可能包括服用含有雌激素和孕激素的避孕药,抗雄激素药或使用胰岛素增敏剂。在所有种族背景下,多毛症影响了约5-15%的女性群体。病理机制多毛症可能是由于雄激素水平升高或毛囊对雄激

Anti-androgenic therapy in young patients and its impact on intensity of hirsutism, acne, menstrual pain intensity and sexuality-a preliminary study复制标题

年轻患者抗雄激素治疗及其对多毛症、痤疮、月经疼痛强度和性欲影响的初步研究

发表时间:2019-10-05

影响因子:0.7

作者: Anna Fuchs

期刊:Ginekol Pol

Hyperandrogenaemia is a very frequent endocrinopathy. It concerns about 7% of women in childbearing age. Its clinical symptoms can be pretty troublesome and often affect our patients’ self-esteem. Oral contraceptives, many times viewed only as a method of contraception, turn out to be very useful in those conditions and offer a variety of non-contraceptive health benefits. They are becoming more and more popular in women with higher levels of androgens. Additionally, they reduce menstrual pain and the amount of blood loss during the menstruation. Moreover, taking hormonal contraceptives regulates the menstrual cycle. Hyperandrogenaemia can be caused by different disease entities, for example polycystic ovary syndrome, obesity, Cushing syndrome, varian secreting androgens, adrenal tumors, adrenal hyperplasia, liver insufficiency. The most common symptoms connected with higher levels of androgens are hirsutism and acne. Hirsutism affects about 5–15% and acne about 6–55% of women, according to epidemiological data. Physiologically, androgens are responsible for hair growth regulation, production and secretion of gonadotropins, wound healing and cutaneous barrier formation. The pathogenesis of acne and hirsutism in hyperandrogenaemia is connected with sebaceous glands, hair follicles and enzymatic reactions in them. Androgens are converted into the dihydrotestosterone (DHT) which has 5 to 10 times higher affinity to androgen receptor than testosterone.

译文

高雄激素血症是一种非常常见的内分泌病。它涉及育龄妇女中约7%。它的临床症状可能非常麻烦,并经常影响我们患者的自尊心。口服避孕药在很多情况下仅被视为避孕方法,在这些情况下非常有用,并提供了多种非避孕健康益处。它们在雄激素水平较高的女性中越来越受欢迎。另外,它们减少月经期间的月经痛和失血量。此外,服用激素避孕药可调节月经周期。高雄激素血症可以由不同的疾病实体引起,例如多囊卵巢综合征,肥胖症,库欣综合征,变种分泌的雄激素,肾上腺肿瘤,肾上腺增生,肝功能不全。与雄激素水平升高相关的最常见症状是多毛症和痤疮。根据流行病学数据,多毛症影响约5-15%的女性,痤疮影响约6-55%的女性。在生理上,雄激素负责头发的生长调节,促性腺激素的产生和分泌,伤口愈合和皮肤屏障的形成。高雄激素血症的痤疮和多毛症的发病机制与皮脂腺,毛囊和其中的酶促反应有关。雄激素被转化为二氢睾丸激素(DHT),其对雄激素受体的亲和力是睾丸激素的5至10倍。