Anti-androgenic therapy in young patients and its impact on intensity of hirsutism, acne, menstrual pain intensity and sexuality-a preliminary study复制标题

年轻患者抗雄激素治疗及其对多毛症、痤疮、月经疼痛强度和性欲影响的初步研究

Hyperandrogenaemia is a very frequent endocrinopathy. It concerns about 7% of women in childbearing age. Its clinical symptoms can be pretty troublesome and often affect our patients’ self-esteem. Oral contraceptives, many times viewed only as a method of contraception, turn out to be very useful in those conditions and offer a variety of non-contraceptive health benefits. They are becoming more and more popular in women with higher levels of androgens. Additionally, they reduce menstrual pain and the amount of blood loss during the menstruation. Moreover, taking hormonal contraceptives regulates the menstrual cycle. Hyperandrogenaemia can be caused by different disease entities, for example polycystic ovary syndrome, obesity, Cushing syndrome, varian secreting androgens, adrenal tumors, adrenal hyperplasia, liver insufficiency. The most common symptoms connected with higher levels of androgens are hirsutism and acne. Hirsutism affects about 5–15% and acne about 6–55% of women, according to epidemiological data. Physiologically, androgens are responsible for hair growth regulation, production and secretion of gonadotropins, wound healing and cutaneous barrier formation. The pathogenesis of acne and hirsutism in hyperandrogenaemia is connected with sebaceous glands, hair follicles and enzymatic reactions in them. Androgens are converted into the dihydrotestosterone (DHT) which has 5 to 10 times higher affinity to androgen receptor than testosterone.

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