Long-term treatment of a VIPoma with somatostatin analogue resulting in remission of symptoms and possible shrinkage of metastases.
用生长抑素类似物长期治疗一个 VIPoma,导致症状缓解和转移灶可能缩小。

摘要

A 43-yr-old-man with metastatic VIPoma in whom the conventional measures of surgery, chemotheraphy, and hepatic artery embolization ultimately failed to control his severe diarrhea, resulting from vasoactive intestinal polypeptide hypersecretion, was treated with a new long-acting somatostatin analogue, SMS 201-995, for 14 mo. SMS 201-995 not only controlled the diarrhea without side effects but appeared to have possibly induced a reduction in metastatic tumor size.

译文

一位 43 岁的转移性血管瘤患者,传统的手术、化疗和肝动脉栓塞措施最终无法控制他因血管活性肠多肽高分泌而导致的严重腹泻, 用一种新的长效生长抑素类似物 SMS 201-995 治疗 14 个月。SMS 201-995 不仅控制了腹泻而没有副作用,而且似乎有可能导致转移肿瘤大小的减少。

Vipoma

内分泌 内分泌肿瘤 临床研究术语
概述  :  

舒血管肠肽瘤是一种罕见的内分泌肿瘤,即过量产生血管活性肠肽。舒血管肠肽瘤通常(约90%)发生于非β胰岛细胞的胰腺,它们有时与1型多发性内分泌肿瘤相关,大约50%-75%的舒血管肠肽瘤是恶性的,但即使它们是良性的,它们也倾向于引起特定的综合征:如引起了严重而慢性的水样腹泻并导致脱水,低钾,胃酸缺乏,酸中毒,潮红和低血压(由血管舒张引起),高钙血症和高血糖综合征。这种综合症称为Verner-Morrison综合症(VMS),WDHA综合症(源于腹泻,低血钾,胃酸缺乏症)或胰腺霍乱综合征(PCS)

Vipoma

释    义   [内科] 舒血管肠肽瘤

例    句   The presence of pancreatic VIPoma should be clinically suspected in all patients with watery diarrhea, particularly when accompanied by a loss of potassium and bicarbonate and a pancreatic mass on imaging. 临床上应怀疑所有水样腹泻患者均存在胰腺舒血管肠肽瘤,特别是伴有钾和碳酸氢盐的流失和影像学检查中的胰腺肿块时。

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