摘要

Evidence points to an association of prolactin to autoimmune diseases. We examined the correlation between hyperprolactinemia and disease manifestations and activity in a large patient cohort. Age- and sex-adjusted prolactin concentration was assessed in 256 serum samples from lupus patients utilizing the LIASON prolactin automated immunoassay method (DiaSorin S.p.A, Saluggia, Italy). Disease activity was defined as present if European Consensus Lupus Activity Measurement (ECLAM) > 2 or Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) > 4. Lupus manifestations were grouped by organ involvement, laboratory data, and prescribed medications. Hyperprolactinemia was presented in 46/256 (18%) of the cohort. Hyperprolactinemic patients had significantly more serositis (40% vs. 32.4%, p = 0.03) specifically, pleuritis (33% vs. 17%, p = 0.02), pericarditis (30% vs. 12%, p = 0.002), and peritonitis (15% vs. 0.8%, p = 0.003). Hyperprolactinemic subjects exhibited significantly more anemia (42% vs. 26%, p = 0.02) and marginally more proteinuria (65.5% vs. 46%, p = 0.06). Elevated levels of prolactin were not significantly associated with other clinical manifestations, serology, or therapy. Disease activity scores were not associated with hyperprolactinemia. Hyperprolactinemia in lupus patients is associated with all types of serositis and anemia but not with other clinical, serological therapeutic measures or with disease activity. These results suggest that dopamine agonists may be an optional therapy for lupus patients with hyperprolactinemia.

译文

证据表明催乳素与自身免疫性疾病有关。我们在一个大型患者队列中检测了高催乳素血症与疾病表现和活动之间的相关性。使用 LIASON 催乳素自动免疫分析法 (DiaSorin S.p.A,Saluggia,意大利),对 256 例狼疮患者的血清样本进行了年龄和性别调整后的催乳素浓度评估。如果欧洲一致同意狼疮活动测量 (ecram)  >  2 或系统性红斑狼疮疾病活动指数 (SLEDAI)  >  4,疾病活动被定义为当前。狼疮表现按器官受累、实验室数据和处方药进行分组。高催乳素血症出现在 46/256 (18%) 的队列中。高催乳素患者有明显更多的浆膜炎 (40% vs.32.4%,p = ¼ 0。 03) 具体而言,胸膜炎 (33% vs.17%,p ¼ = ¼ 0。 02),心包炎 (30% vs.12%,p   =  0。 002),而腹膜炎 (15% vs.0.8%,p   =  0。 003)。高催乳素受试者表现出明显更多的贫血 (42% 对 26%,p = 65.5%) 和略多的蛋白尿 (46% 对,p =)。催乳素水平升高与其他临床表现、血清学或治疗无关。疾病活动评分与高泌乳素血症无关。狼疮患者的高催乳素血症与所有类型的浆膜炎和贫血相关,但与其他临床、血清学治疗措施或疾病活动无关。这些结果表明多巴胺激动剂可能是治疗高催乳素血症的狼疮患者的可选疗法。

Hyperprolactinemia

内分泌 催乳激素水平升高 疾病
概述  :  

高催乳素血症是以血液中称为催乳激素的激素水平高为特征的状态。催乳素是由垂体产生的,在怀孕期间乳房的发育中起着至关重要的作用。虽然高催乳素血症在怀孕和哺乳期间被认为是完全正常的,但由于疾病和药物使用,它可能在其他时间发生。高催乳素血症可影响男性和女性,导致月经不调和勃起功能障碍。病理原因高催乳素血症的一个常见原因是垂体上的肿瘤,称为催乳素瘤,肿瘤可产生高水平的催乳激素。这些肿瘤可大可小,通常是良性的,这意味着它们没有癌变。大型肿瘤也可能导致头痛,视力问题或两者兼而有之。催乳素瘤在女性中比在男性

Hyperprolactinemia

释    义   n. 乳素血症;[内科] 高泌乳素血症

例    句   Hyperprolactinemia is one of the common diseases to cause the amenorrhea, galactorrhea and dysgenesis. 高催乳素血症是引起闭经、溢乳、不孕等常见疾病之一。

请扫描右侧二维码,免费查看词汇专业知识背景