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首页 > 医学词汇大全 > Hyperprolactinemia
Hyperprolactinemia

内分泌

关键词内分泌 疾病 催乳激素水平升高

词汇介绍

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解析

Hyperprolactinemia

释    义   n. 乳素血症;[内科] 高泌乳素血症

例    句   Hyperprolactinemia is one of the common diseases to cause the amenorrhea, galactorrhea and dysgenesis. 高催乳素血症是引起闭经、溢乳、不孕等常见疾病之一。

概述

高催乳素血症是以血液中称为催乳激素的激素水平高为特征的状态。催乳素是由垂体产生的,在怀孕期间乳房的发育中起着至关重要的作用。虽然高催乳素血症在怀孕和哺乳期间被认为是完全正常的,但由于疾病和药物使用,它可能在其他时间发生。高催乳素血症可影响男性和女性,导致月经不调和勃起功能障碍。病理原因高催乳素血症的一个常见原因是垂体上的肿瘤,称为催乳素瘤,肿瘤可产生高水平的催乳激素。这些肿瘤可大可小,通常是良性的,这意味着它们没有癌变。大型肿瘤也可能导致头痛,视力问题或两者兼而有之。催乳素瘤在女性中比在男性

Evidence for hyperprolactinemia in migraineurs: a systematic review and meta-analysis复制标题

偏头痛患者高催乳素血症的证据: 系统回顾和荟萃分析

发表时间:2019-08-23

影响因子:2.5

作者: Ali Noori-Zadeh

期刊:Neurol Sci

Migraine is characterized by recurrent headaches that are often throbbing in sensation and frequently unilateral in location and severe in intensity. From the etiology aspects, it is thought that migraine is a form of neuro-vascular headache, i.e., a disorder in which during an attack, the neural abnormality occurs and results in blood vessel dilation, which, in turn, causes pain induction and brain nociceptive activation. Thus, migraine is best understood as a primary disorder of the brain tissue which is triggered by primary brain biochemical homeostasis instabilities and disturbances and vascular tone changes are known as the secondary event. Although migraine attacks may occur at any age, it is notable that they are frequently appeared in childhood, especially during puberty periods. It affects women more than men as the 1-year migraine prevalence is nearly threefold higher and the cumulative lifetime incidence is more than twofold higher in comparison with men. The most prevalent subtype is migraine without aura, including menstrual migraine in women. Interestingly, migraine is more prevalent in women during reproductive years and it is well known that there is a strong relationship between headache and endocrine homeostasis, particularly in relation to ovarian hormones. It is thought that hormones acting in the hypothalamus-pituitary-ovaries axis are critically important in the pathophysiology of migraine. Of this axis, prolactin is secreted from anterior pituitary gland and synthesized by a variety of immune system cells. Even though there is a plethora of publications describing prolactin blood concentrations from 1970s to 2010s, however, there is not any meta-analysis in the evidence-based medicine field and actually, whether prolactin circulatory concentrations can be altered during migraine pathogenesis is an open question yet. Therefore, investigating prolactin blood levels in migraineurs may pave the way to underpin our understanding about migraine pathophysiology at biochemical levels. In the current report, the prolactin blood levels in the migraine subjects investigated using meta-analysis under random-effects model and SMD as the effect size.

译文

偏头痛的特征是经常发作的头痛反复发作,并且经常单侧发生,强度剧烈。从病因学的角度来看,偏头痛是神经血管性头痛的一种形式,即一种在发作期间神经异常发生并导致血管扩张的疾病,继而引起疼痛感和大脑伤害性激活。因此,最好将偏头痛理解为脑组织的原发性疾病,它是由原发性脑生物化学稳态不稳定和紊乱以及血管紧张度变化引发的,称为继发性事件。尽管偏头痛发作可能发生在任何年龄,但值得注意的是,它们通常出现在儿童时期,尤其是在青春期。与男性相比,它对女性的影响要大得多,因为1年偏头痛的患病率几乎是男性的三倍,并且终身累积发病率是男性的两倍以上。最普遍的亚型是无先兆偏头痛,包括女性的月经偏头痛。有趣的是,偏头痛在生殖年期的女性中更为普遍,众所周知,头痛与内分泌稳态之间存在密切的关系,尤其是与卵巢激素有关。据认为,作用于下丘脑-垂体-卵巢轴的激素在偏头痛的病理生理中至关重要。催乳素从垂体前叶分泌,并由多种免疫系统细胞合成。尽管有很多出版物描述了从1970年代到2010年代的催乳素血药浓度,但是,在循证医学领域没有进行任何荟萃分析,实际上,是否可以在偏头痛发病过程中改变催乳素的血药浓度是一个悬而未决的问题。然而。因此,调查偏头痛患者的催乳素血液水平可能为巩固我们对偏头痛病理生理学在生化水平上的理解铺平道路。在本报告中,偏头痛受试者中的催乳素血水平在随机效应模型下以荟萃分析进行了调查,并以SMD作为效应量。