摘要

Evidence points to an association of prolactin to autoimmune diseases. We examined the correlation between hyperprolactinemia and disease manifestations and activity in a large patient cohort. Age- and sex-adjusted prolactin concentration was assessed in 256 serum samples from lupus patients utilizing the LIASON prolactin automated immunoassay method (DiaSorin S.p.A, Saluggia, Italy). Disease activity was defined as present if European Consensus Lupus Activity Measurement (ECLAM) > 2 or Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) > 4. Lupus manifestations were grouped by organ involvement, laboratory data, and prescribed medications. Hyperprolactinemia was presented in 46/256 (18%) of the cohort. Hyperprolactinemic patients had significantly more serositis (40% vs. 32.4%, p = 0.03) specifically, pleuritis (33% vs. 17%, p = 0.02), pericarditis (30% vs. 12%, p = 0.002), and peritonitis (15% vs. 0.8%, p = 0.003). Hyperprolactinemic subjects exhibited significantly more anemia (42% vs. 26%, p = 0.02) and marginally more proteinuria (65.5% vs. 46%, p = 0.06). Elevated levels of prolactin were not significantly associated with other clinical manifestations, serology, or therapy. Disease activity scores were not associated with hyperprolactinemia. Hyperprolactinemia in lupus patients is associated with all types of serositis and anemia but not with other clinical, serological therapeutic measures or with disease activity. These results suggest that dopamine agonists may be an optional therapy for lupus patients with hyperprolactinemia.

译文

证据表明催乳素与自身免疫性疾病有关。我们在一个大型患者队列中检测了高催乳素血症与疾病表现和活动之间的相关性。使用 LIASON 催乳素自动免疫分析法 (DiaSorin S.p.A，Saluggia，意大利)，对 256 例狼疮患者的血清样本进行了年龄和性别调整后的催乳素浓度评估。如果欧洲一致同意狼疮活动测量 (ecram)  >  2 或系统性红斑狼疮疾病活动指数 (SLEDAI)  >  4，疾病活动被定义为当前。狼疮表现按器官受累、实验室数据和处方药进行分组。高催乳素血症出现在 46/256 (18%) 的队列中。高催乳素患者有明显更多的浆膜炎 (40% vs.32.4%，p = ¼ 0。 03) 具体而言，胸膜炎 (33% vs.17%，p ¼ = ¼ 0。 02)，心包炎 (30% vs.12%，p   =  0。 002)，而腹膜炎 (15% vs.0.8%，p   =  0。 003)。高催乳素受试者表现出明显更多的贫血 (42% 对 26%，p = 65.5%) 和略多的蛋白尿 (46% 对，p =)。催乳素水平升高与其他临床表现、血清学或治疗无关。疾病活动评分与高泌乳素血症无关。狼疮患者的高催乳素血症与所有类型的浆膜炎和贫血相关，但与其他临床、血清学治疗措施或疾病活动无关。这些结果表明多巴胺激动剂可能是治疗高催乳素血症的狼疮患者的可选疗法。