摘要

Methimazole, carbimazole, and propylthiouracil (PTU) are the mainstays of antithyroid drug therapy. Adverse effects of these drugs have been documented in less than 15% of patients undergoing treatment for hyperthyroidism. Common problems include fever, skin rash, urticaria, arthralgias, and arthritis. Vasculitis associated with antineutrophil anticytoplasmic antibodies (ANCA) has been reported on several occasions following treatment with PTU. However, vasculitis rarely appears to be associated with carbimazole. We report the clinical history of a woman with a necrotizing glomerulonephritis and pulmonary hemorrhage associated with carbimazole therapy.

译文

甲巯咪唑、卡莫唑和丙硫氧嘧啶 (PTU) 是抗甲状腺药物治疗的主要药物。这些药物的不良反应记录在不到 15% 接受甲状腺功能亢进治疗的患者中。常见的问题包括发烧、皮疹、荨麻疹、关节痛和关节炎。与抗中性粒细胞抗胞浆抗体 (ANCA) 相关的血管炎已在 PTU 治疗后多次报告。然而，血管炎似乎很少与卡莫唑有关。我们报告了一名女性坏死性肾小球肾炎和与卡莫唑治疗相关的肺出血的临床病史。