Effects of lorcaserin on fat and lean mass loss in obese and overweight patients without and with type 2 diabetes mellitus: the BLOSSOM and BLOOM-DM studies.
Lorcaserin 对没有或患有 2 型糖尿病的肥胖和超重患者的脂肪和脂肪质量损失的影响: BLOSSOM 和 BLOOM-DM 的研究。
antiobesity drug appetite control body composition clinical trial obesity therapy
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摘要

Body composition was determined using dual-energy X-ray absorptiometry (DXA) in a subset of patients without (BLOSSOM) and with (BLOOM-DM) type 2 diabetes who received diet and exercise counselling along with either lorcaserin 10 mg twice daily or placebo. DXA scans were performed on study day 1 (baseline), week 24 and week 52. Baseline demographics of the subpopulations (without diabetes, n = 189; with diabetes, n = 63) were similar between studies and representative of their study populations. At week 52, patients without diabetes on lorcaserin lost significantly more fat mass relative to those on placebo (-12.06% vs -5.93%; p = 0.008). In patients with diabetes, fat mass was also decreased with lorcaserin relative to placebo (-9.87% vs -1.65%; p < 0.05). More fat mass was lost in the trunk region with lorcaserin compared with placebo (without diabetes: -3.31% vs -2.05%; with diabetes: -3.65% vs -0.36%). Weight loss with lorcaserin was associated with a greater degree of fat mass loss than lean mass loss, and most of the fat mass lost for patients without and with diabetes was from the central region of the body.

译文

在没有 (BLOSSOM) 和有 (BLOOM-DM) 的患者中,使用双能 x射线吸收测定法 (DXA) 确定身体成分 2 型糖尿病患者接受饮食和运动咨询,同时接受每日两次 10 毫克的 lorcaserin 或安慰剂。DXA 扫描在研究第一天 (基线) 、第 24 周和第 52 周进行。亚人群 (无糖尿病,n = 189; 有糖尿病,n = 63) 的基线人口统计在研究和他们研究人群的代表之间是相似的。在 12.06% 周,服用 lorcaserin 的无糖尿病患者比服用安慰剂的患者减少了更多的脂肪量 (-5.93% vs-0.008; p =)。在糖尿病患者中,与安慰剂相比,使用 lorcaserin 的脂肪量也减少了 (-9.87% vs-1.65%; p <0.05)。与安慰剂相比,使用 lorcaserin 的躯干区域减少了更多的脂肪量 (没有糖尿病:-3.31% vs-2.05%; 糖尿病:-3.65% vs-0.36%)。使用 lorcaserin 减肥与更大程度的脂肪量损失比瘦肉量损失相关, 没有糖尿病和患有糖尿病的病人失去的大部分脂肪来自身体的中央区域。

Lorcaserin

内分泌 内分泌 治疗药物
概述  :  

氯卡色林用于帮助肥胖或超重且患有与体重有关的医学问题的成年人减轻体重,并防止体重增加。氯卡色林必须与减少卡路里的饮食和运动计划一起使用,氯卡色林是一类称为5-羟色胺受体激动剂的药物,它通过增加饱腹感而起作用,从而减少了食物的摄入。氯卡色林可作为片剂和口服缓释(长效)片剂使用,缓释片剂通常每天与食物或不与食物一起服用,每天大约在同一时间服用氯卡色林。不良反应最常见的不良反应是恶心,呕吐,便秘,腹泻,疲劳,上呼吸道感染,尿路感染,背痛,头痛,头晕,和皮疹。如氯卡色林影响血清素受体,血清素综合征可

Lorcaserin

释    义   n. 氯卡色林

例    句   Wall Street analysts considered lorcaserin the most likely of three diet drugs before the FDA to succeed because it seemed to present fewer safety issues. 华尔街分析家认为氯卡色林很有可能在美国食品药品监督管理局批准之前三种减肥药中最成功的一个,因为该药物安全问题最少。

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