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The integrated value of serum procollagen III peptide over time predicts hepatic hydroxyproline content and stainable collagen in a model of dietary cirrhosis in the rat.
随着时间的推移,血清前胶原 III 肽的综合值预测大鼠饮食肝硬化模型中的肝脏羟脯氨酸含量和可染色胶原。

摘要

To determine whether a serum parameter of collagen metabolism, serum procollagen type III peptide, correlated with hepatic collagen in a model of diet-induced fibrosis, rats were fed a control or cirrhogenic diet for 6 months and treated with either subcutaneous vehicle or the hepatoprotective prostaglandin 16,16-dimethyl prostaglandin E2 (100 micrograms per kg) twice daily. Pair-fed rats from each group were killed after 2, 4 or 6 months. The value of serum procollagen type III peptide to body weight integrated over time (Kt) correlated linearly with hepatic hydroxyproline content (r = 0.97) at killing time t. Good correlations were also seen between Kt and histopathological assessment of aniline blue-stainable collagen (r = 0.93) and between the histopathology and hydroxyproline content (r = 0.97). Rats receiving 16,16-dimethyl prostaglandin E2 had lower values of all three parameters compared to rats receiving vehicle, confirming the previously demonstrated hepatoprotective effect of 16,16-dimethyl prostaglandin E2. The excellent correlation between Kt and the two other traditional parameters of hepatic collagen suggest that sequential measurements of serum procollagen type III peptide can be used to predict alterations in liver collagen deposition in rats.

译文

为了确定胶原代谢的血清参数,血清 ⅲ型前胶原肽,是否与饮食诱导的纤维化模型中的肝脏胶原相关, 大鼠被喂食 6 个月的对照组或肝硬化饮食,并用皮下载体或保肝前列腺素 16,16-二甲基前列腺素 E2 (100 微克/公斤) 每日两次。在 2 、 4 或 6 个月后,每组的配对喂养大鼠被杀死。在杀死时间 t,血清 ⅲ型前胶原肽与体重随时间的积分值 (Kt) 与肝脏羟脯氨酸含量 (r = 0.97) 呈线性相关。Kt 和苯胺蓝染色胶原蛋白的组织病理学评估 (r = 0.93) 以及组织病理学和羟脯氨酸含量 (r = 0.97) 之间也有良好的相关性。与接受载体的大鼠相比,接受 16-二甲基前列腺素 E2 的大鼠所有三个参数的值都较低,证实了先前证明的 16-二甲基前列腺素 E2 的保肝作用。Kt 和肝胶原的另外两个传统参数之间的极好的相关性表明,血清 ⅲ型前胶原肽的连续测量可以用来预测大鼠肝脏胶原沉积的改变。

Procollagen-III-Peptide

消化 肝纤维化诊断 临床研究术语
概述  :  

Ⅲ型前胶原转变成原胶原的过程中,其氨基端和羧基端的肽被内切酶切下后游离在血液中,其血液中的含量随胶原合成活跃而增加。检测血清中前胶原及其末端肽和胶原的分解片断,能够从胶原代谢水平反映肝脏纤维化情况。Ⅲ型胶原主要在肝纤维化早期增加,测定Ⅲ型胶原的代谢产物对肝纤维化早期诊断有意义。 检测方法放射免疫法(RIA)。 正常值均值为100ngL,>150ngL为异常。各实验室应建立自己的参考区间。 临床意义与评价PIIIP是肝纤维化敏感的早期化学标志物,反映纤维化动

procollagen  [prəu'kɔlədʒən]

释义   n. 原骨胶原

例句   Objective:Investigation of the effect of integrin on fibroblasts from scleroderma in the production of procollagen.  目的:研究硬皮病成纤维细胞整合素表达对成纤维细胞合成原胶原的影响。

 

peptide 英 [ˈpeptaɪd] 美 [ˈpeptaɪd]

释义   n. [生化] 缩氨酸

例句   A peptide is a short chain of the amino-acid molecules that are the ultimate components of proteins。一个缩氨酸是一个短链的氨基酸分子,而氨基酸是最终形成蛋白质的分子。


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