消化
词汇介绍
拓展阅读
解析
procollagen [prəu'kɔlədʒən]
释义 n. 原骨胶原
例句 Objective:Investigation of the effect of integrin on fibroblasts from scleroderma in the production of procollagen. 目的:研究硬皮病成纤维细胞整合素表达对成纤维细胞合成原胶原的影响。
peptide 英 [ˈpeptaɪd] 美 [ˈpeptaɪd]
释义 n. [生化] 缩氨酸
例句 A peptide is a short chain of the amino-acid molecules that are the ultimate components of proteins。一个缩氨酸是一个短链的氨基酸分子,而氨基酸是最终形成蛋白质的分子。
概述
概述
Ⅲ型前胶原转变成原胶原的过程中,其氨基端和羧基端的肽被内切酶切下后游离在血液中,其血液中的含量随胶原合成活跃而增加。检测血清中前胶原及其末端肽和胶原的分解片断,能够从胶原代谢水平反映肝脏纤维化情况。Ⅲ型胶原主要在肝纤维化早期增加,测定Ⅲ型胶原的代谢产物对肝纤维化早期诊断有意义。
检测方法
放射免疫法(RIA)。
正常值
均值为100ngL,>150ngL为异常。各实验室应建立自己的参考区间。
临床意义与评价
PIIIP是肝纤维化敏感的早期化学标志物,反映纤维化动态过程;也是慢性肝炎活动性、预后和免疫治疗疗效判断与监测指标。
(1)肝硬化早期,PIIIP升高早于光镜下形态学观察到的肝脏纤维增生发生之前;肝硬化晚期PIIIP减低或正常;伴纤维化的原发性肝癌PIIIP升高;
(2)PIIIP升高无器官特异性,也见于肝纤维化以外的肝病,但肝纤维化时升高幅度最大;
(3)反映肝内炎症和灶性坏死(急性肝炎、慢性活动性肝炎、酒精性肝炎);
(4)慢性迁延性肝炎和脂肪肝PIIIP多正常或轻度升高;如慢性肝炎PIIIP持续升高,提示有肝硬化的趋势;
(5)血清PP水平随年龄増长有较大变化。儿童至青少年血清PIIIP水平高于成年人。
循环PIIINP水平识别2型糖尿病伴或不伴非酒精性脂肪肝患者脂肪组织相关炎症
发表时间:2018-07-10
影响指数:4.8
作者: Barchetta I
期刊:Diabetes/Metabolism Research and Reviews
The Procollagen type III aminoterminal Propeptide (PIIINP) is a circulating peptide resulting from biosynthesis and degradation of type III collagen1 and represents an early marker of tissue remodelling and fibrosis in several conditions such as heart failure2, atherosclerosis3, interstitial lung disease4 and pulmonary artery hypertension5 . Serum PIIINP has been demonstrated to increase consistently with the hepatic damage progression in the course of chronic liver diseases 6-10 and, because of the tight correlation between circulating PIIINP concentration and tissue collagen production, it displays a role in risk stratification of subjects with advanced liver fibrosis. 8-11 Within chronic hepatopathies, non-alcoholic fatty liver disease (NAFLD) is the most common cause of abnormal hepatic function in Western countries, with a prevalence ranging from 20-25% in general population up to 60-90% in patients with type 2 diabetes mellitus (T2DM) and obesity12 .
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