摘要

Chronic pancreatitis (CP) is a debilitating condition associated with substantial morbidity and mortality 1,2. Prolonged inflammation results in destruction of healthy pancreatic parenchyma and development of tissue fibrosis 3. This causes irreversible loss of exocrine function, which manifests as impaired production and secretion of digestive enzymes in response to ingested nutrients4, as well as permanent loss of endocrine function. Common secondary consequences of CP include therefore pancreatic exocrine insufficiency (PEI), and pancreatogenic diabetes mellitus (DM) 1,2,5,6. PEI leads to maldigestion, with resultant malabsorption of fat, protein, and  fat-soluble vitamins, leading ultimately to nutritional deficiencies7,8. Approximately 35–50% of patients with CP are believed to develop PEI within 10–15 years of disease onset2 and require pancreatic enzyme replacement therapy (PERT) to restore a normal nutritional status 5,9.

译文

慢性胰腺炎（CP）是一种使人虚弱的病症，与大量发病和死亡1,2有关。 长时间的炎症导致健康的胰腺实质破坏和组织纤维化发展3。这会导致外分泌功能不可逆转的丧失，表现为因摄入营养物质而导致的消化酶的产生和分泌受损4，以及内分泌功能的永久丧失。 因此，CP的常见继发后果包括胰腺外分泌功能不全（PEI）和胰源性糖尿病（DM）1,2,5,6。 PEI导致消化不良，从而导致脂肪，蛋白质和脂溶性维生素吸收不良，最终导致营养缺乏7,8。 据信，大约35-50％的CP患者在发病10-15年内会发展为PEI，需要进行胰酶替代疗法（PERT）才能恢复正常的营养状态5,9。