摘要

Chronic pancreatitis (CP) is a debilitating condition associated with substantial morbidity and mortality 1,2. Prolonged inflammation results in destruction of healthy pancreatic parenchyma and development of tissue fibrosis 3. This causes irreversible loss of exocrine function, which manifests as impaired production and secretion of digestive enzymes in response to ingested nutrients4, as well as permanent loss of endocrine function. Common secondary consequences of CP include therefore pancreatic exocrine insufficiency (PEI), and pancreatogenic diabetes mellitus (DM) 1,2,5,6. PEI leads to maldigestion, with resultant malabsorption of fat, protein, and  fat-soluble vitamins, leading ultimately to nutritional deficiencies7,8. Approximately 35–50% of patients with CP are believed to develop PEI within 10–15 years of disease onset2 and require pancreatic enzyme replacement therapy (PERT) to restore a normal nutritional status 5,9.

译文

慢性胰腺炎(CP)是一种使人虚弱的病症,与大量发病和死亡1,2有关。 长时间的炎症导致健康的胰腺实质破坏和组织纤维化发展3。这会导致外分泌功能不可逆转的丧失,表现为因摄入营养物质而导致的消化酶的产生和分泌受损4,以及内分泌功能的永久丧失。 因此,CP的常见继发后果包括胰腺外分泌功能不全(PEI)和胰源性糖尿病(DM)1,2,5,6。 PEI导致消化不良,从而导致脂肪,蛋白质和脂溶性维生素吸收不良,最终导致营养缺乏7,8。 据信,大约35-50%的CP患者在发病10-15年内会发展为PEI,需要进行胰酶替代疗法(PERT)才能恢复正常的营养状态5,9。

Pancreatic Exocrine Insufficiency

消化 消化吸收不良症 疾病
概述  :  

胰腺外分泌功能不全(pancreatic exocrine insufficiency,PEI)是指由慢性胰腺炎、囊性纤维化或胰腺手术等引起人体自身胰酶分泌不足而产生的脂肪泻、体重减轻等消化吸收不良症。 发病机制与病因发病机制:(1)胰腺实质功能衰退或损伤, 胰酶合成能力下降;(2)胰管阻塞, 胰液流出受阻;(3)分泌反馈失衡, 对胰酶生成的刺激减弱。病因:主要包括慢性胰腺炎(chronic pancreatitis, CP)、急性胰腺炎(acute pancreatitis, A

pancreatic 英 [ˌpæŋkriˈætɪk] 美 [ˌpæŋkriˈætɪk]

释义   adj. 胰的;胰腺的

例句   They found it stimulated the secretion of insulin in pancreatic cells in the laboratory. 他们发现,在实验室这种天然物能刺激胰腺细胞分泌胰岛素。

 

exocrine 英 [ˈeksəʊkraɪn; ˈeksəʊkrɪn] 美 [ˈeksəkrɪn,ˈeksəkriːn]

释义   adj. 外分泌的

例句   Saliva is secreted from the exocrine gland. 唾液是由外分泌腺分泌出来的。

 

insufficiency 英 [ˌɪnsəˈfɪʃənsi] 美 [ˌɪnsəˈfɪʃənsi]

释义   n. 不足,不充分;机能不全;不适当

例句   Objective:To analyze the insufficiency in time limit monitoring of new edition doctor workstation of HIS. 目的:探讨分析新版医生工作站在时限监控设计中存在的不足。


请扫描右侧二维码,免费查看词汇专业知识背景