Pancreatic exocrine insufficiency and cardiovascular risk in patients with chronic pancreatitis: A prospective, longitudinal cohort study复制标题

慢性胰腺炎患者胰腺外分泌功能不全与心血管风险: 一项前瞻性、纵向队列研究

Chronic pancreatitis (CP) is a debilitating condition associated with substantial morbidity and mortality 1,2. Prolonged inflammation results in destruction of healthy pancreatic parenchyma and development of tissue fibrosis 3. This causes irreversible loss of exocrine function, which manifests as impaired production and secretion of digestive enzymes in response to ingested nutrients4, as well as permanent loss of endocrine function. Common secondary consequences of CP include therefore pancreatic exocrine insufficiency (PEI), and pancreatogenic diabetes mellitus (DM) 1,2,5,6. PEI leads to maldigestion, with resultant malabsorption of fat, protein, and  fat-soluble vitamins, leading ultimately to nutritional deficiencies7,8. Approximately 35–50% of patients with CP are believed to develop PEI within 10–15 years of disease onset2 and require pancreatic enzyme replacement therapy (PERT) to restore a normal nutritional status 5,9.

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