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首页 > 医学词汇大全 > Fecal Immunochemical Test
Fecal Immunochemical Test

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关键词消化 诊断方式 大肠癌程序性筛查

词汇介绍

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解析

fical 英 [ˈfiːkl] 美 [ˈfiːkl]

释义   adj. 排泄物的;残渣的;糟粕的

例句   Fecal matter should move through your colon easily and in a short time. 粪便的问题应该通过您的结肠容易在很短的时间。

 

immunochemical 英 [,ɪmjʊnəʊ'kemɪkəl]

释义   adj. 免疫化学的

例句   Within the last year, have you had a fecal occult blood test (FOBT) or a fecal immunochemical test (FIT)? 过去一年内,是否曾接受过大便隐血测试或大便免疫化学测试?

 

test 英 [test]

释义   n. 测验,考查;测试;检验;化验

v. 测验;化验,检查;试验,测试;考验

例句   You should test for the overload at each point of the cycle. 您应当在周期的每个时刻都测试超负荷。


概述

粪便免疫化学检测法FIT(fical immunochemical test,FIT) 是利用单克隆或多克隆抗体直接检测人粪便中的血红蛋白,不受进食食物的影响。定性 FIT 是在粪便中血红蛋白含量超过一定阈值后会产生可视性的颜色变化,定量 FIT 则可测量数值,当超过一定的正常值范围后被定义为阳性。 适应症可用于大肠癌程序性筛查。 临床应用(1)推荐每年1次采样进行FIT检查;(2)推荐选择定量检测方法而非定性检测方法;(3)建议选择较低的阈值(如20μg/g或

Lower Abnormal Fecal Immunochemical Test Cut-Off Values Improve Detection of Colorectal Cancer in System-Level Screens复制标题

较低的异常粪便免疫化学检测临界值可提高系统水平筛查中的结直肠癌检测

发表时间:2019-05-11

影响因子:8.0

作者: Emily Berry

期刊:Clinical Gastroenterology and Hepatology

Colorectal cancer (CRC) is the second leading cause Q16 of cancer death in the United States (ACS-CFF). Q15 Screening can reduce CRC incidence and mortality,1–6 but participation is suboptimal among underserved populations, particularly minorities and the uninsured.2,7–10 Noninvasive tests for CRC screening such as the fecal immunochemical test (FIT) have been linked to higher participation rates,6,11–13 but have lower sensitivity for CRC and advanced adenoma than colonoscopy. Some FITs are quantitative and measure the absolute hemoglobin (Hgb) concentration within a stool sample. One strategy to improve neoplasia detection among individuals preferring FIT would be to decrease the Hgb concentration that would indicate an abnormal test  result requiring diagnostic colonoscopy. Prior work has suggested that a lower threshold can improve neoplasia detection; a meta-analysis of FIT performance found that  using a lower hemoglobin concentration cut-off value to designate an abnormal FIT optimized sensitivity for CRC: 89% for a cut-off value of less than 20 mg hemoglobin/g  feces vs 70% for cut-off values of 20 to 50 mg hemoglobin/g feces.14 A challenge of this approach, however, particularly in settings with constrained colonoscopy capacity,  is that decreasing the threshold also may increase colonoscopy demand. In the United States in particular, real-world data specific to the impact of using a lower Hgb concentration threshold for diagnostic colonoscopy demand and neoplasia detection when implemented within screening programs are sparse.

译文

结直肠癌(CRC)是美国癌症死亡(ACS-CFF)的第二大Q16主要原因。 Q15筛查可以降低CRC的发生率和死亡率,1–6,但是参与不足的人群(尤其是少数族裔和未保险人群)的参与率不是最佳的。2,7–10 CRC筛查的非侵入性检查(如粪便免疫化学测试(FIT))与更高参与率[6,11–13],但对结肠癌和晚期腺瘤的敏感性低于结肠镜检查。一些FIT是定量的,可以测量粪便样本中的绝对血红蛋白(Hgb)浓度。在喜欢FIT的个体中改善肿瘤形成检测的一种策略是降低Hgb浓度,这表明需要诊断性结肠镜检查的异常检测结果。先前的工作表明较低的阈值可以改善肿瘤形成的检测。对FIT性能的荟萃分析发现,使用较低的血红蛋白浓度临界值来指定异常的FIT对CRC的优化敏感性:对于小于20 mg血红蛋白/ g粪便的临界值,89%的临界值小于70 mg血红蛋白/ g粪便的初始值在20至50 mg之间。14然而,尤其是在结肠镜检查能力受限的情况下,这种方法的挑战在于降低阈值也可能会增加结肠镜检查的需求。特别是在美国,当在筛查程序中实施时,特定于将较低Hgb浓度阈值用于诊断结肠镜检查需求和瘤形成检测的影响的特定现实世界数据很少。