Lynch 英 [lɪntʃ] 美 [lɪntʃ]
释义 v. 处以私刑；以私刑绞死
n. (Lynch) （美）林奇（人名）
例句 Francis Lynch called it nummular neurodermatitis. Francis Lynch称之为钱币状神经性皮炎。
syndrome 英 ['sɪndrəʊm] 美 ['sɪndrəʊm]
释义 n. [临床] 综合症状；并发症状；校验子；并发位
例句 Staphylococcal toxic syndrome,atypical presentation of Kawasaki syndrome or staphylococcal skin syndrome？ 金黄色葡萄球菌毒性综合征,非典型川崎综合征或金黄色葡萄球菌皮肤综合征?
作者： Giorgia Mori
期刊：Frontiers in Microbiology
Lynch syndrome (LS) is a dominantly inherited condition with incomplete penetrance, characterized by high predisposition to colorectal cancer (CRC), endometrial and ovarian cancers, as well as to other tumors. LS is associated with constitutive DNA mismatch repair (MMR) gene defects, and carriers of the same pathogenic variants can show great phenotypic heterogeneity in terms of cancer spectrum. In the last years, human gut microbiota got a foothold among risk factors responsible for the onset and evolution of sporadic CRC, but its possible involvement in the modulation of LS patients' phenotype still needs to be investigated. In this pilot study, we performed 16S rRNA gene sequencing of bacterial DNA extracted from fecal samples of 10 postoperative LS female patients who had developed colonic lesions (L-CRC) or gynecological cancers (L-GC). Our preliminary data show no differences between microbial communities of L-CRC and L-GC patients, but they plant the seed of the possible existence of a fecal microbiota pattern associated with LS genetic background, with Faecalibacterium prausnitzii, Parabacteroides distasonis, Ruminococcus bromii, Bacteroides plebeius, Bacteroides fragilis and Bacteroides uniformis species being the most significantly over-represented in LS patients (comprising both L-CRC and L-GC groups) compared to healthy subjects.