消化
词汇介绍
拓展阅读
解析
insulin 英 [ˈɪnsjəlɪn] 美 [ˈɪnsəlɪn]
释义 n. [生化][药] 胰岛素
例句 Therefore, insulin resistance alone can not be the determining pathogenic factor in T2DM. 因此,胰岛素抵抗本身不能成为T2DM的决定因素。
概述
概述
胰岛素是由胰脏内的胰岛β细胞受内源性或外源性物质如葡萄糖、乳糖、核糖、精氨酸、胰高血糖素等的刺激而分泌的一种蛋白质激素。胰岛β细胞中储备胰岛素约200U,每天分泌约40U。空腹时,血浆胰岛素浓度是5~15μU/mL。进餐后血浆胰岛素水平可增加5~10倍。胰岛素是机体内唯一降低血糖的激素,同时促进糖原、脂肪、蛋白质合成。外源性胰岛素主要用来治疗糖尿病。
结构
胰岛素由A、B两条肽链组成。人胰岛素(Insulin Human) A链有11种21个氨基酸,B链有15种30个氨基酸,共16种51个氨基酸组成。其中A7(Cys)-B7(Cys)、A20(Cys)-B19(Cys)四个半胱氨酸中的巯基形成两个二硫键,使A、B两链连接起来。此外A链中A6(Cys)与A11(Cys)之间也存在一个二硫键。
分类
胰岛素主要有两种分类方法,按来源分类和按作用时间分类,其中按作用时间长短分类与胰岛素的治疗方案密切相关,是最常使用的胰岛素分类方法。
(1)根据胰岛素的来源不同,可分为动物胰岛素、重组人胰岛素和胰岛素类似物三类;
(2)根据胰岛素的作用时间不同,分为超短效胰岛素、短效胰岛素、中效胰岛素、长效胰岛素及预混胰岛素五类。
影响胰岛素分泌的因素
(1)血浆葡萄糖浓度;
(2)进食含蛋白质较多的食物;
(3)进餐后胃肠道激素增加;
(4)自主神经功能状态 迷走神经兴奋时促进胰岛素分泌;交感神经兴奋时则抑制胰岛素分泌。
生物学作用
(1)药理作用 治疗糖尿病、消耗性疾病。促进血循环中葡萄糖进入肝细胞、肌细胞、脂肪细胞及其他组织细胞合成糖原使血糖降低,促进脂肪及蛋白质的合成。
(2)生理作用 调节糖、脂肪及蛋白质代谢。
(3)其他 胰岛素可促进钾离子和镁离子穿过细胞膜进入细胞内;可促进脱氧核糖核酸(DNA)、核糖核酸(RNA)及三磷酸腺苷(ATP)的合成。
适应症
(2)II型糖尿病;
(3)围术期,出现严重的急性并发症或应激状态时需临时使用胰岛素度过危险期,如糖尿病酮症酸中毒、高渗性高血糖状态、乳酸酸中毒、感染等;
(4)出现严重慢性并发症,如糖尿病足、重症糖尿病肾病等;合并一些严重的疾病,如冠心病、脑血管病、血液病、肝病等
(5)妊娠糖尿病及糖尿病合并妊娠的妇女,妊娠期、分娩前后、哺乳期,如血糖不能单用饮食控制达到要求目标值时,需用胰岛素治疗,禁用口服降糖药。
(6)继发性糖尿病和特异性糖尿病人。
胰岛素反应
(1)全身反应 ①低血糖反应;②过敏反应;③胰岛素性水肿;④屈光失常。
(2)局部反应 ①注射局部皮肤红肿、发热及皮下有小结发生;②皮下脂肪萎缩或增生,脂肪萎缩成凹陷性皮脂缺失,多见于女青年及小儿大腿、腹壁等注射部位;皮下组织增生成硬块,多见于男性臀部等注射部位。③皮下脂肪纤维化增生。
(3)不少病人在胰岛素治疗过程中产生抗体或由于受体敏感性下降,对胰岛素需要量逐渐增大,形成胰岛素抗药性。
Use and Discontinuation of Insulin Treatment Among Adults Aged 75 to 79 Years With Type 2 Diabetes复制标题
75 ~ 79岁2型糖尿病患者使用和停止胰岛素治疗
发表时间:2019-09-23
影响指数:20.8
作者: Jonathan Z Weiner
期刊:JAMA Internal Medicine
Existing guidelines recommend individualizing glycemic targets based on health status but do not make specific recommendations about insulin use. We studied the prevalence of insulin use and discontinuation among a cohort of 75-yearolds with type 2 diabetes to test the hypothesis that older adults with poor health would be less likely to use insulin and bemore likely to discontinue insulin over time. We found that nearly 1 in 5 individuals were receiving insulin therapy at age 75 years. Insulin use was most prevalent among those in poor health, whereas subsequent insulin discontinuation after age 75 years was most likely in healthier patients, even after accounting for level of glycemic control. The results of this study suggest that neither prevalent insulin use nor subsequent insulin discontinuation among older patients is closely aligned with current recommendations to incorporate health status (in conjunction with life expectancy and patient preferences) when making treatment decisions. These patterns remained evident even when accounting for level of glycemic control. For example, we would expect to find less insulin discontinuation among relatively healthy patients with poor glycemic control (HbA1c≥8.5%) relative to less healthy patients because these healthier patients are more likely to realize long-term clinical benefit with the tighter control that would be expected from continuing insulin therapy. However, Figure 3B demonstrates that discontinuation follows the opposite pattern: patients with poor health are least likely to discontinue insulin.
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