首页 > 医学词汇大全 > Esophageal Atresia
Esophageal Atresia

消化

关键词消化 疾病 消化道发育畸形

词汇介绍

拓展阅读

解析

esophageal 英 [iː,sɒfə'dʒiːəl] 美 [,isə'fædʒɪəl]
释义   adj. 食管的;食道的
例句   Research and application of tumor markers in esophageal squamous cell carcinoma. 肿瘤标志物在食管鳞状细胞癌中的研究与应用。

atresia  [ə'triʒə]
释义   n. 闭锁(畸形);无孔;不通(如子宫,输卵管)
例句   Objective: To discuss the feasibility and operation sequence for congenital atresia of esophagus by stomach pipe. 目的:探讨应用胃管初步诊断先天性食管闭锁的可行性及操作程序。

概述

先天性食管闭锁(esophageal atresia,EA)是胚胎发育3 周~6 周,在食管发育过程中的空泡期发生障碍引起的严重消化道发育畸形。以早产儿、未成熟儿较为多见,食管闭锁的发病比例为 1:2500~4500。 患儿合并肺炎、先天性心脏病,如不及时处理,可致患儿死亡。国内病死率27%~43.5%,国11%~34%。 有文献报道术后严重的肺部并发症和吻合口瘘是患儿死亡的主要原因,吻合口瘘的发生率为5%~42%。  临床表现唾液不能下咽,反流入口腔,出生后即流涎、吐白

Predictors of the Performance of Early Antireflux Surgery in Esophageal Atresia复制标题

食管闭锁早期抗反流手术效果的预测因素

发表时间:2019-05-06

影响因子:3.7

作者: Berengere Franc¸ois

期刊:The Journal of Pediatrics

Esophageal atresia is a rare congenital malformation characterized by a lack of continuity of the upper gastrointestinal tract with or without a tracheoesophageal  fistula. Esophageal atresia occurs in 1 in 2400-4500 births.1 The prognosis for esophageal atresia has benefited from recent advances in medical and surgical care; the survival rate is now >95%, and an increasing number of patients live to adulthood.2–5 Gastroesophageal reflux disease (GERD) is the most frequent associated condition and occurs in the majority of patients with esophageal atresia.6 The cause of GERD in esophageal atresia involves abnormal extrinsic and intrinsic innervation of the esophagus, which leads to dysmotility and anomalies in sphincter tone.6–8 GERD can have potentially severe complications, such as peptic esophagitis, gastric metaplasia, Barrett esophagus, anastomotic stricture, aggravation of laryngomalacia, and asthma. GERD associated with esophageal atresia often is refractory to antireflux medication, and up to 40% of patients may require antireflux surgery.

译文

食管闭锁是一种罕见的先天性畸形,其特征是上消化道缺乏连续性,伴或不伴有气管食管瘘。食管闭锁症发生在2400-4500例婴儿中,其中1例发生。1食管闭锁症的预后受益于医学和外科治疗的最新进展。目前,存活率> 95%,并且越来越多的患者能够成年。2–5胃食管反流病(GERD)是最常见的伴发疾病,在大多数食道闭锁患者中都有发生。6GERD的病因食道闭锁患者的食管异常内在和内在神经支配异常,导致运动障碍和括约肌张力异常。6-8GERD可能具有严重的并发症,如消化道食管炎,胃化生,巴雷特食管,吻合口狭窄,恶化和哮喘。与食管闭锁相关的GERD通常难以接受抗反流药物治疗,多达40%的患者可能需要抗反流手术6。