摘要

BACKGROUND & AIMS:There are few data on the prevalence of gastroesophageal reflux disease (GERD) in the United States. We performed a population-based study to determine the prevalence of GERD symptoms and persistent GERD symptoms despite use of proton pump inhibitors (PPIs).
METHODS:We conducted the National Gastrointestinal Survey in 2015 using MyGiHealth, an app that guides participants through National Institutes of Health gastrointestinal PROMIS surveys. Primary outcomes were prevalence of GERD symptoms in the past and persistence of GERD symptoms (heartburn or regurgitation 2 or more days in past week) among participants taking PPIs. Population weights were applied to the data and multivariable regression was used to adjust for confounding.
RESULTS:Among 71,812 participants, 32,878 (44.1%) reported having had GERD symptoms in the past and 23,039 (30.9%) reported having GERD symptoms in the last week. We also found that 35.1% of those who had experienced GERD symptoms were currently on therapy (55.2% on PPIs, 24.3% on histamine-2 receptor blockers, and 24.4% on antacids). Among 3,229 participants taking daily PPIs, 54.1% had persistent GERD symptoms. Younger individuals, women, Latinos, and participants with irritable bowel syndrome or Crohn's disease were more likely to have continued symptoms, even when taking PPIs.
CONCLUSIONS:Using a population-based survey, we found GERD symptoms to be common: 2 of 5 participants have had GERD symptoms in the past and 1 of 3 had symptoms in the last week. We also found that half of PPI users have persistent symptoms. Given the significant effect of GERD on quality of life, further research and development of new therapies are needed for patients with PPI-refractory GERD symptoms.

译文

背景与目的: 在美国几乎没有关于胃食管反流病 (GERD) 患病率的数据。我们进行了一项基于人群的研究,以确定尽管使用质子泵抑制剂 (PPIs),GERD 症状和持续性 GERD 症状的患病率。
方法: 我们使用 MyGiHealth 进行了 2015年的全国胃肠调查,MyGiHealth 是一款通过美国国立卫生研究院胃肠 PROMIS 调查指导参与者的应用程序。主要结果是过去服用 PPIs 的参与者中 GERD 症状的患病率和 GERD 症状的持续性 (胃灼热或反胃 2 天或以上)。人口权重应用于数据,多元回归用于调整混淆。
结果: 在 71,812 名参与者中,32,878 人 (44.1%) 报告过去有 GERD 症状,23,039 人 (30.9%) 报告上周有 GERD 症状。我们还发现,35.1% 经历过 GERD 症状的人目前正在接受治疗 (PPIs 55.2%,组胺-2 受体阻滞剂 24.3%,抗酸剂 24.4%)。在每天服用 PPIs 的 3,229 名参与者中,54.1% 的人有持续性的 GERD 症状。年轻的个体、女性、拉丁美洲人和患有肠易激综合征或克罗恩病的参与者更有可能出现持续的症状,即使在服用质子泵抑制剂时也是如此。
结论: 通过一项基于人群的调查,我们发现 GERD 症状很常见: 5 名参与者中有 2 人过去有过 GERD 症状,3 名参与者中有 1 人上周有过症状。我们还发现一半的 PPI 使用者有持续性症状。鉴于 GERD 对生活质量的显著影响,需要对患有 PPI 难治性 GERD 症状的患者进一步研究和开发新疗法。

Proton Pump Inhibitor

消化 抑制胃酸分泌 药物
概述  :  

质子泵抑制药(proton pump inhibitor ,PPI)是继H2受体阻断药后的一类重要的抑制胃酸分泌药,也是目前抑制胃酸分泌作用最强的一类药物。目前临床常见的本类药物有奥美拉唑,兰索拉唑,泮托拉唑,雷贝拉唑和艾司奥美拉唑等。 作用机制质子泵(H+-K+-ATP酶)抑制剂抑酸作用并不在于阻断各种受体,而是进入胃壁细胞分泌小管的高酸环境中与H +结合形成有活性的次黄酸和次黄酰胺,与H+ -K+ -ATP酶的巯基脱水偶联,导致体内H+-K+-ATP酶活性永

proton 英 [ˈprəʊtɒn] 美 [ˈproʊtɑ:n]

释义   n. [物] 质子

例句   There is more than one proton in the nucleus..有超过一个以上的质子在核子里。

 

pump 英 [pʌmp] 美 [pʌmp]

释义   n. 泵;泵送;无带浅帮女鞋;平底轻便鞋

v. 抽吸;喷出;注入;射向目标;打气;(非正式)盘问;剧烈上下晃动;让……使用大量药物;洗胃;增加数值

例句   This is called the lymphatic pump. 这叫作淋巴泵。

 

inhibitor 英 [ɪnˈhɪbɪtə(r)] 美 [ɪnˈhɪbɪtɚ]

释义   n. [助剂] 抑制剂,抗化剂;抑制者

例句   An ErbB2 tyrosine kinase inhibitor down-regulates survivin, inducing apoptosis. 一种ErbB2酪氨酸激酶抑制剂下调生存素表达,诱导细胞凋亡。


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