摘要

OBJECTIVES:The aim of this study was to assess the role of vascular adhesion molecule 1 (VCAM-1) in patients with hereditary haemochromatosis (HH) with or without arthropathy.
METHODS:Sera from a large cross-sectional cohort of unselected HH patients (n=147) were obtained and compared to an age-matched and sex-matched control group. Serum levels of VCAM-1 were measured by ELISA and were correlated with clinical measures.
RESULTS:VCAM-1 serum levels were elevated in HH patients as compared to matched controls (mean 913±456 vs 654±451 ng/ml, p<0.0001). Within the HH patient group, VCAM-1 levels were much higher in patients with arthropathy and joint replacement surgery. VCAM-1 levels correlated well with radiographic measures of HH arthropathy (r=0.36, p<0.0001). Multivariate regression analysis confirmed a highly significant association of VCAM-1 serum levels and the presence of HH arthropathy, independent from diabetes, body mass index and age.
CONCLUSIONS:VCAM-1 serum levels emerge as a biomarker for haemochromatosis arthropathy.

译文

目的: 本研究的目的是评估血管粘附分子 1 (VCAM-1) 在有或没有关节病的遗传性血色病 (HH) 患者中的作用。
方法: 从未选择的 HH 患者 (n = 147) 的大型横断面队列中获得血清,并与年龄匹配和性别匹配的对照组进行比较。采用 ELISA 法测定血清 VCAM-1 水平,并与临床指标进行相关性分析。
结果: 与匹配的对照组相比,HH 患者的 VCAM-1 血清水平升高 (平均 913 ± 456 vs 654 ± 451 ng/ml,p <0.0001)。在 HH 患者组中,关节病和关节置换手术患者的 VCAM-1 水平要高得多。VCAM-1 水平与 HH 关节病的影像学指标有很好的相关性 (r = 0.36,p <0.0001)。多变量回归分析证实了 VCAM-1 血清水平与 HH 关节病存在高度显著关联,独立于糖尿病、体重指数和年龄。
结论: VCAM-1 血清水平成为血色病关节病的生物标志物。

Hereditary Haemochromatosis

消化 含铁血色素沉着症 疾病
概述  :  

遗传性血色病(Hereditary haemochromatosis,HHC),也称原发性血色病(Primary haemochromatosis)或特发性血色病(Idiopathic haemochromatosis)是常染色体隐性遗传性疾病,由于铁过度吸收及转运障碍,致使铁在肝、脾、胰、皮肤、肾上腺、心、脑垂体、关节等组织、器官实质细胞中过量沉积,造成多器官功能障碍,呈现以皮肤色素沉着、肝硬化及糖尿病三大临床特征为代表的一系列临床表现。 临床表现(1)成年男性多见。早期多数为无

hereditary  [həˈredɪtri] [həˈredɪteri]

释义   adj. 遗传的;世袭的;世代相传的

n. 遗传类

例句   Some forms of mental retardation are hereditary.一些智力发育迟缓就是因遗传而造成的。

 

haemochromatosis  [,hɛmo',krəʊmə'təʊsɪs]

释义   n. [内科] 血色病

[皮肤] 血色素沉着症

例句   You may actually have haemochromatosis-a condition where the body absorbs too much iron and which can be toxic, leading to a build up of iron in organs, liver or heart failure and even death. 实际上,你或许身患血色病,由于身体里吸收了太多的铁元素而中毒,致使铁元素在各个器官堆积,最终导致肝脏或心脏衰竭,甚至死亡。


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