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首页 > 医学词汇大全 > Ursodeoxycholic Acid
Ursodeoxycholic Acid

消化

关键词消化 药物 胆结石,胆汁淤积性肝病

词汇介绍

拓展阅读

解析

ursodeoxycholic 

释义   n. 熊去氧胆酸

例句   To explore the curative effect of ursodeoxycholic acid(UDCA) on infantile hepatitis syndrome(IHS).

探讨熊去氧胆酸(UDCA)治疗婴儿肝炎综合征(IHS)的疗效。

 

acid  [ˈæsɪd] [ˈæsɪd]

释义   n. 酸;<>迷幻药

adj. 酸的;讽刺的;刻薄的

例句   He treats this substance with the acid more carefully than before.

他比以前更小心地用酸来处理这种物质。


概述

熊去氧胆酸,主要成分是3a,7β-二羟基-5β-胆甾烷-24-酸,用于增加胆汁酸分泌,并使胆汁成分改变,降低胆汁中胆固醇及胆固醇脂,有利于胆结石中的胆固醇逐渐溶解。口服后95%由小肠吸收,在肝内与甘氨酸或牛磺酸结合,经胆汁排入肠腔,形成肠肝循环,仅有少量药物进人体循环,血药浓度很低。 药理作用能抑制肝脏胆固醇合成,增加胆固醇在胆汁中的溶解度,并使Oddi氏括约肌松弛,有溶石、利胆作用,另有保肝、降低甘油三酯浓度、抑制消化酶分泌的作用。 临床作用用于预防及治疗胆固醇结石及结

Ursodeoxycholic acid in pregnancy?复制标题

熊去氧胆酸在妊娠?

发表时间:2019-08-31

影响因子:19.0

作者: de Vries E

期刊:Journal of Hepatology

There are no guideline recommendations for UDCA treatment during lactation since data on UDCA  treatment and bile acid levels in breast milk are scarce, but toxicity of UDCA when administered at  recommended doses in cholestatic neonates and infants is not known. Only a few case reports have addressed the issue of UDCA in breastmilk. One German case report analyzed patient’s breast milk by high pressure liquid chromatography while she was treated with UDCA at a dose of 750mg/day. No UDCA was detected, in contrast to the more hydrophobic cholic acid, deoxycholic acid and lithocholic acid 67. A more recent case report analyzed bile acids in breast milk at a UDCA dosage up to 1500mg/day and found no effect of UDCA at increasing doses on breast milk bile acid content; development of the child was normal 68. The most relevant study on UDCA therapy and breast milk was performed in ICP patients 69. Bile acid excretion in colostrum from 16 lactating ICP patients was compared to that in colostrum of five healthy lactating mothers. In ICP patients treated with UDCA compared to non-treated women excretion of total bile acid in colostrum was substantially decreased. Accumulation of UDCA in colostrum was very limited and the concentration ingested by the nursing infant irrelevant. The breastfeeding infant would be exposed to less than 0.01% of the UDCA administered to the mother with an estimated total daily dose of approximately 12 µg. No side effects were encountered in breastfeeding infants whose mothers continued UDCA treatment during lactation 45.

译文

由于UDCA治疗和母乳中胆汁酸水平的数据很少,因此在哺乳期间没有关于UDCA治疗的指南建议,但是在胆汁淤积的新生儿和婴儿中以推荐剂量给药时UDCA的毒性尚不清楚。只有少数病例报告解决了母乳中的UDCA问题。一份德国病例报告通过高压液相色谱分析患者的母乳,同时用UDCA以750mg /天的剂量治疗。没有检测到UDCA,与更疏水的胆酸,脱氧胆酸和石胆酸67相反。最近的一个病例报告分析了UDCA剂量高达1500mg /天的母乳中的胆汁酸,并发现UDCA在增加剂量时没有效果关于母乳中胆汁酸的含量;儿童的发育是正常的68.在ICP患者中进行了最相关的UDCA治疗和母乳研究69.将16名哺乳期ICP患者的初乳中的胆汁酸排泄与5名健康哺乳母亲的初乳进行比较。在用UDCA治疗的ICP患者中,与未治疗的女性相比,初乳中总胆汁酸的排泄显着降低。初乳中UDCA的积累非常有限,护理婴儿摄入的浓度无关紧要。母乳喂养婴儿将接触少于0.01%的UDCA给予母亲,估计总日剂量约为12μg。在哺乳期母亲继续接受UDCA治疗的母乳喂养婴儿中没有遇到任何副作用45。