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THE RELATION OF THE SPLEEN TO BLOOD DESTRUCTION AND REGENERATION AND TO HEMOLYTIC JAUNDICE : XIV. CHANGES IN THE BLOOD FOLLOWING DIVERSION OF THE SPLENIC BLOOD FROM THE LIVER. A CONTROL STUDY OF THE EFFECTS OF SPLENECTOMY.
脾脏与血液破坏和再生的关系以及与溶血性黄疸的关系: 十四。脾脏血液从肝脏转移后血液的变化。脾切除术效果的对照研究。

摘要

1. In dogs whose splenic veins have been ligated or transplanted into the inferior vena cava, or in which an Eck fistula has been made, an anemia occurs which resembles that following splenectomy and shows the same general variation in degree and duration. 2. The resistance of the red cells to hypotonic salt solution is quickly increased, sometimes coincident with and sometimes preceding the anemia. As a rule, it gradually returns to normal in about the same length of time as it takes the anemia to disappear, but may remain increased for longer periods. 3. There is an initial leukocytosis, involving at first the polymorphonuclear leucocytes and transitional cells. As the total leukocytosis diminishes there is both a relative and actual increase of small lymphocytes and usually of eosinophils. This may either be temporary or last during the rest of the period of observation and differs from the ordinary postoperative leukocytosis. 4. Ligation of the splenic vein is followed by considerable atrophy of the spleen, but not by necrosis or thrombosis. There is rarely adequate new vein formation. The other operations cause little or no change in the spleen. 5. Whether the disturbances as described are due to the loss of a certain volume of blood to the liver, or, as has been previously suggested, to the loss of a splenic hormone, it is impossible to say. If the former is true, the method of production of the anemia still remains unexplained. It is evident, furthermore, that the latter theory has also no value unless it is assumed that this hormone must be activated by passage through the liver.

译文

1. 在脾静脉被结扎或移植到下腔静脉的狗中,或者在其中形成了 Eck 瘘管, 贫血的发生类似于脾切除术后的贫血,并在程度和持续时间上显示出相同的总体变化。2.红细胞对低渗盐溶液的抵抗力迅速增强,有时与贫血同时发生,有时先于贫血发生。通常,在贫血消失的时间长度上,它会逐渐恢复正常,但可能会持续更长时间。3.最初的白细胞增多,首先涉及多形核白细胞和移行细胞。随着总白细胞增多的减少,小淋巴细胞和嗜酸性粒细胞的相对和实际增加。这可能是暂时的,也可能在观察的剩余时间内持续,不同于普通的术后白细胞增多。4.脾静脉结扎术之后是脾脏相当大的萎缩,但不是坏死或血栓形成。很少有足够的新静脉形成。其他手术很少或没有引起脾脏的变化。5. 所描述的紊乱是否是由于肝脏损失了一定量的血液,或者,如前所述,是由于脾脏激素的损失, 这是不可能说的。如果前者是真的,贫血的产生方法仍然无法解释。此外,很明显,后一种理论也没有价值,除非假设这种激素必须通过肝脏激活。

Hemolytic Jaundice

消化 胆红素 疾病
概述  :  

血清总胆红素在34 umol/L以上,临床上即表现有黄疸。巩膜、皮肤无黄染,而血清总胆红素超过正常值,则称为隐性黄疸。溶血性黄疸(hemolytic jaundice)指由于各种原因造成的红细胞被大量破坏,在网状内皮细胞中生成的胆红素过多,超过肝摄取、结合与排泄的能力,造成血中间接胆红素浓度异常增高引起的黄疸。各种引起大量溶血的原因都可造成溶血性黄疸。 病因凡能引起溶血的疾病都可引发溶血性黄疸。常见病因如下:(1)先天性溶血性贫血 如海洋性贫血、遗传性球形红细胞增多症等;

hemolytic [hi:'mɒlɪtɪk]  [hi:'mɒlɪtɪk]

释义   adj. [生理][免疫] 溶血的

例句   Objective:To compare the prediction effect on hemolytic disease of the newborn between monocyte monolayer assay and antibody titre.

目的单核细胞单层试验和抗体效价测定试验预判新生儿溶血病的预测效果。

 

jaundice  [ˈdʒɔ:ndɪs]  [ˈdʒɔndɪs, ˈdʒɑn-]

释义   n. 黄疸;偏见;乖僻

vt. 使怀偏见;使患黄疸

例句   Leptospirosis causes severe jaundice, kidney failure and bleeding in the lungs.

钩端螺旋体导致严重的黄疸、肾衰竭和肺出血。


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