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Glutamine

消化

关键词消化 药物 临床用药

词汇介绍

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解析

glutamine 英 ['glu:təmi:n] 美 ['glu:təmi:n]

释义   n. 谷氨酰胺

例句   To observe the effect of glutamine on gut barrier function and antioxidative capacity in rats with radiation damage.

观察谷氨酰胺对放射损伤大鼠肠粘膜屏障功能和抗氧化能力的影响。


概述

谷氨酰胺,学名2-氨基-4-氨甲酰基丁酸,是谷氨酸的酰胺。L-谷氨酰胺是蛋白质合成中的编码氨基酸,哺乳动物非必需氨基酸,在体内可以由葡萄糖转变而来。谷氨酰胺可用于治疗胃及十二指肠溃疡、胃炎及胃酸过多,也用于改善脑功能。 性状白色结晶或晶性粉末,溶于水,不溶于甲醇、乙醇、醚、苯、丙酮、氯仿和乙酸乙酯,无臭,稍有甜味。在中性溶液中不稳定,在醇、碱或热水中易分解成谷氨醇或丙酯化为吡咯羧醇。 功能(1)增强免疫系统;(2)参与合成谷胱甘肽(一种重要的抗氧化剂);(3)胃肠道管腔细

Association between Brain and Plasma Glutamine Levels in Healthy Young Subjects Investigated by MRS and LC/MS复制标题

用MRS和LC/MS研究健康青年受试者脑和血浆谷氨酰胺水平的相关性

发表时间:2019-07-19

影响因子:4.2

作者: Yuhei Takado

期刊:Nutrients

Both glutamine (Gln) and glutamate (Glu) are known to exist in plasma and brain. However, despite the assumed relationship between brain and plasma, no studies have clarified the association between them. Proton magnetic resonance spectroscopy (MRS) was sequentially performed twice, with a 60-min interval, on 10 males and 10 females using a 3T scanner. Blood samples for liquid chromatography–mass spectrometry (LC/MS) to measure Gln and Glu concentrations in plasma were collected during the time interval between the two MRS sessions. MRS voxels of interest were localized at the posterior cingulate cortex (PCC) and cerebellum (Cbll) and measured by the SPECIAL sequence. Spearman’s correlation coefficient was used to examine the association between brain and plasma metabolites. The Gln concentrations in PCC (mean of two measurements) were positively correlated with Gln concentrations in plasma (p < 0.01, r = 0.72). However, the Glu concentrations in the two regions were not correlated with those in plasma. Consideration of the different dynamics of Gln and Glu between plasma and brain is crucial when addressing the pathomechanism and therapeutic strategies for brain disorders such as Alzheimer’s disease and hepatic encephalopathy.

译文

已知谷氨酰胺(Gln)和谷氨酸(Glu)都存在于血浆和脑中。然而,尽管假设大脑和血浆之间的关系,但没有研究澄清它们之间的关联。使用3T扫描仪对10只雄性和10只雌性依次进行质子磁共振波谱(MRS)两次,间隔60分钟。在两个MRS期间之间的时间间隔期间收集用于液相色谱 - 质谱(LC / MS)的血液样品以测量血浆中的Gln和Glu浓度。感兴趣的MRS体素定位于后扣带皮层(PCC)和小脑(Cbll),并通过SPECIAL序列测量。 Spearman的相关系数用于检查脑和血浆代谢物之间的关联。 PCC中的Gln浓度(两次测量的平均值)与血浆中的Gln浓度正相关(p <0.01,r = 0.72)。然而,两个区域的Glu浓度与血浆中的浓度无关。在解决诸如阿尔茨海默病和肝性脑病等脑疾病的病理机制和治疗策略时,考虑血浆和脑之间Gln和Glu的不同动态是至关重要的。