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首页 > 医学词汇大全 > Liver Biopsy
Liver Biopsy

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关键词消化 实验技术 肝组织标本采集

词汇介绍

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解析

liver 英 [ˈlɪvə(r)] 美 [ˈlɪvɚ]

释义   n. 肝脏;生活者,居民

例句   They also found particles in the liver cells of patients with hepatitis.

他们在肝炎病人的肝细胞也发现了这种微粒。

 

biopsy 英 [ˈbaɪɒpsi] 美 [ˈbaɪɑ:psi]

释义   n. 活组织检查;活组织切片检查;切片检查法

例句   Open lung biopsy demonstrated GVHD.

开胸活检证实为GVHD。

概述

肝穿刺活体组织检查术( liver biopsy)简称肝活检,是采取肝组织标本的一种简易手段。 适应证(1)原因不明的肝大、黄疸、肝功能异常;(2)原因不明的发热,怀疑为恶性组织细胞病者;(3)肝脏实质性占位性病变的鉴别;(4)代谢性肝病,如脂肪肝、肝淀粉样变性、血色病等的诊断。 禁忌证有明显出血倾向、大量腹水、肝外阻塞性黄疸,或疑为肝棘球蚴病、肝血管瘤者。 操作方法(1)体位患者取仰卧位,身体右侧靠床沿,并将右手置于枕后。(2)选择穿刺点肝组织活检应在超声或C

Transjugular Liver Biopsy: Safe Even in Patients With Severe Coagulopathies and Multiple Biopsies复制标题

经颈静脉肝活检: 即使在严重凝血病和多次活检患者中也是安全的

发表时间:2019-07-01

影响因子:4.6

作者: Megan J. Sue

期刊:Clinical and Translational Gastroenterology

Transjugular liver biopsy (TJLB) is a safe and efficacious method of obtaining hepatic tissue samples for histopathologic analysis (1–3). First developed in 1964 as an alternative to percutaneous liver  biopsy, TJLB can be safely performed in high-risk patients or those requiring simultaneous hepatic hemodynamic measurements(1,2,4–6). By using a vascular access route rather than a percutaneous  one, TJLB greatly reduces the risk of hemorrhage secondary to compromise of the hepatic arterial or portal venous system (7,8). However, TJLB is not without risk. Minor complications including  abdominal pain, capsular perforation, neck hematoma, fever, and hypotension have been associated with the procedure (9–11). In addition, extremely rare major complications such as  intraperitoneal hemorrhage, retroperitoneal hemorrhage, and death have also been reported (4,8,10,11). However, because any potential post-biopsy bleeding may occur intravascularly, the risk of some of the major complications is minimized (1,6). As such, a transjugular approach is the preferred biopsy method in high-risk patients: those with coagulopathy, coagulation disorders, or high-volume ascites and those not clinically stable enough to tolerate percutaneous procedures (1,4). Diagnostic efficacy and the quality of specimens obtained by TJLB are comparable to those obtained by a percutaneous route, with success rates approaching 87%–98% (4,10,11).

译文

经颈静脉肝活检(TJLB)是一种安全有效的获取肝组织样本进行组织病理学分析的方法(1-3)。最初开发于1964年作为经皮肝活检的替代方案,TJLB可以安全地在高风险患者或需要同时进行肝血流动力学测量的患者中进行(1,2,4-6)。通过使用血管通路而不是经皮通路,TJLB大大降低了继发于肝动脉或门静脉系统损害的出血风险(7,8)。但是,TJLB并非没有风险。包括腹痛,囊膜穿孔,颈部血肿,发热和低血压在内的轻微并发症与手术相关(9-11)。此外,还报告了非常罕见的主要并发症,如腹腔内出血,腹膜后出血和死亡(4,8,10,11)。然而,由于血管内可能发生任何潜在的活检后出血,因此可以将一些主要并发症的风险降至最低(1,6)。因此,经颈静脉入路是高风险患者首选的活检方法:凝血功能障碍,凝血功能障碍或大量腹水,以及临床上不足以耐受经皮手术的患者(1,4)。 TJLB获得的标本的诊断效果和质量与通过经皮途径获得的相当,成功率接近87%-98%(4,10,11)。