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首页 > 医学词汇大全 > Colon Carcinoma
Colon Carcinoma

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关键词消化 疾病 胃肠道肿瘤

词汇介绍

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解析

colon  英 [ˈkəʊlən] 美 [ˈkoʊlən]

释义   n. [解剖] 结肠;冒号(用于引语、说明、例证等之前);科郎(哥斯达黎加货币单位)

复数 colons

例句   These tests allow the surgeon to look inside of the colon.

以上这些检查可以让外科医生看到结肠内部的情况。

 

carcinoma 英 [ˌkɑ:sɪˈnəʊmə] 美 [ˌkɑ:rsɪˈnoʊmə]

释义   n. [肿瘤] 癌

复数 carcinomas或carcinomata

例句   So if this is an example of lobular carcinoma, I think it is very atypical.

因此,这例如果是小叶癌,我认为是一种非常不典型的病例。 

概述

结肠癌(colon carcinoma)是胃肠道中常见的恶性肿瘤。以40~50岁年龄组发病率最高。病因尚未十分明确,但有些疾病如家族性息肉病,已被公认为癌前期病变;结肠腺瘤、溃疡性结肠炎以及结肠血吸虫病肉牙肿,与结肠癌的发生有较密切的关系。 病因和发病机制目前认为是环境因素与遗传因素综合作用的结果。(一)病因(1)心理因素;(2)肠道感染;(3)食物因素;(4)家庭和遗传因素;(5)自主神经功能异常。(二)病理生理(1)胃肠运动紊乱;(2)内脏感觉功能异常;(3)肠道通透性増加。&

Ruthenium Complexes With Piplartine Cause Apoptosis Through MAPK Signaling by a p53-Dependent Pathway in Human Colon Carcinoma Cells and Inhibit Tumor Development in a Xenograft Model复制标题

钌与吡帕汀复合物通过p53-Dependent途径通过MAPK信号通路在人结肠癌细胞中引起细胞凋亡,并在异种移植模型中抑制肿瘤的发展

发表时间:2019-07-03

影响因子:4.4

作者: Gonçalo Moniz Institute

期刊:Frontiers in Oncology

Ruthenium complexes with piplartine,[Ru(piplartine) (dppf) (bipy)](PF6)2(1)and [Ru(piplartine) (dppb)(bipy)](PF6)2 (2) (dppf=1,1-bis(diphenyl phosphino) ferrocene;dppb=1,4-bis(diphenyl phosphino) butane and bipy=2,2'-bipyridine), were recently synthesized and displayed more potent cytotoxicity than piplartine in different cancer cells, regulated RNA transcripts of several apoptosis-related genes, and induced reactive oxygen species (ROS)-mediated apoptosis in human colon carcinoma HCT116 cells. The present work aimed to explore the underlying mechanisms through which these ruthenium complexes induce cell death in HCT116 cells in vitro, as well as their in vivo action in a xenograft model. Both complexes significantly increased the percentage of apoptotic HCT116 cells, and co-treatment with inhibitors of JNK/SAPK, p38 MAPK, and MEK, which inhibits the activation of ERK1/2, significantly reduced the apoptosis rate induced by these complexes. Moreover, significant increase in phospho-JNK2 (T183/Y185), phospho-p38α (T180/Y182), and phospho-ERK1 (T202/Y204) expressions were observed in cells treated with these complexes, indicating MAPK-mediated apoptosis. In addition, co-treatment with a p53 inhibitor (cyclic pifithrin-α) and the ruthenium complexes significantly reduced the apoptosis rate in HCT116 cells, and increased phospho-p53 (S15) and phospho-histone H2AX (S139) expressions, indicating induction of DNA damage and p53-dependent apoptosis. Both complexes also reduced HCT116 cell growth in a xenograft model. Tumor mass inhibition rates were 35.06, 29.71, and 32.03% for the complex 1 (15 μmol/kg/day), complex 2 (15 μmol/kg/day), and piplartine (60 μmol/kg/day), respectively. These data indicate these ruthenium complexes as new anti-colon cancer drugs candidates.

译文

与哌啶,[Ru(piplartine)(dppf)(bipy)](PF6)2(1)和[Ru(piplartine)(dppb)(bipy)](PF6)2(2)(dppf = 1,1)的钌配合物最近合成了双(二苯基膦基)二茂铁; dppb = 1,4-双(二苯基膦基)丁烷和bipy = 2,2'-联吡啶),并且在不同的癌细胞中显示出比piplartine更强的细胞毒性,受调节的RNA转录物几种凋亡相关基因,诱导活性氧(ROS)介导的人结肠癌HCT116细胞凋亡。目前的工作旨在探索这些钌络合物在体外诱导HCT116细胞中细胞死亡的潜在机制,以及它们在异种移植模型中的体内作用。两种复合物均显着增加凋亡细胞HCT116的百分比,并且与抑制ERK1 / 2活化的JNK / SAPK,p38MAPK和MEK抑制剂共同处理显着降低了这些复合物诱导的细胞凋亡率。此外,在用这些复合物处理的细胞中观察到磷酸-JNK2(T183 / Y185),磷酸-p38α(T180 / Y182)和磷酸-ERK1(T202 / Y204)表达的显着增加,表明MAPK介导的细胞凋亡。此外,与p53抑制剂(环状pifithrin-α)和钌复合物的共同处理显着降低了HCT116细胞的凋亡率,并增加了磷酸化p53(S15)和磷酸化组蛋白H2AX(S139)的表达,表明诱导DNA损伤和p53依赖性细胞凋亡。两种复合物还在异种移植模型中减少HCT116细胞生长。复合物1(15μmol/ kg /天),复合物2(15μmol/ kg /天)和piplartine(60μmol/ kg /天)的肿瘤质量抑制率分别为35.06,29.71和32.03%。这些数据表明这些钌配合物是新的抗结肠癌候选药物。