chronic 英 [ˈkrɒnɪk] 美 [ˈkrɑ:nɪk]
释 义 adj. 慢性的；长期的；习惯性的
同根词 adv. chronically 长期地；慢性地；习惯性地
例 句 They think his illness is acute rather than chronic.
pancreatitis 英 [ˌpænkrɪə'taɪtɪs] 美 [ˌpænkrɪr'taɪtɪs]
释 义 n. [内科] 胰腺炎 复数 pancreatititides
同根词 pancreatic adj. 胰的；胰腺的
例 句 Necrosectomy for infected necrotizing pancreatitis.
作者： Robinson SM
Chronic pancreatitis (CP) is a fibrotic disorder of the pancreas leading to clinical sequelae like pain and an excess of comorbidity including cardiovascular disease and cancers. The aim of this study was to determine the relationship between systemic inflammation and quality of life in patients with CP. Patients were prospectively recruited and underwent a quality of life assessment (EORTC QLQ-C30 and PAN 28). The serum inflammatory profile was assessed using an MSD 30-plex array. The relationship between clinical variables, inflammatory cytokines and quality of life was determined by a GLMMANOVA and the individual impact of signifcant variables evaluated by a second ANOVA. In total, 211 patients with a median age of 53 years were recruited across 5 European centres. Gender, age, nicotine and alcohol abuse were clinical variables associated with altered quality of life. Systemic inflammation with high levels of pro-inflammatory cytokines (Eotaxin, IL-1β, IL-7, IL-8, IL-12/IL-23p40, IL-12p70, IL-13, IL-16, IP-10, MCP-1, MCP-4, MDC, MIP-1a, TARC, TNFß) was associated with diminished quality of life in general and specifc domains including pain, physical and cognitive functioning. As conclusion, CP is associated with a systemic inflammatory response that has a negative impact on quality of life and accelerates aging.