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首页 > 医学词汇大全 > Chronic Pancreatitis
Chronic Pancreatitis

消化

关键词消化 疾病 临床疾病

词汇介绍

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解析

chronic  [ˈkrɒnɪk]  [ˈkrɑ:nɪk] 

释    义   adj. 慢性的;长期的;习惯性的

n. (Chronic)人名;()克罗尼克

同根词   adv. chronically 长期地;慢性地;习惯性地

例    句   They think his illness is acute rather than chronic.

他们认为他的病是急性的而非慢性的。

 

pancreatitis  [ˌpænkrɪə'taɪtɪs] [ˌpænkrɪr'taɪtɪs]

释    义   n. [内科] 胰腺炎 复数 pancreatititides

同根词   pancreatic adj. 胰的;胰腺的

例    句   Necrosectomy for infected necrotizing pancreatitis.

感染性坏死性胰腺炎坏死组织清除术。

概述

 慢性胰腺炎( chronic pancreatitis,CP)是胰腺组织结构和(或)功能出现不可逆的持续性损害。结构异常包括慢性炎症、腺泡萎缩、胰管变形、部分或广泛纤维化、钙化、假性囊肿形成;功能异常以胰腺外分泌功能障碍造成吸收不良和内分泌功能障碍造成糖尿病为突出临床表现。CP的发病率很难准确统计,有结构异常的可无任何症状,而有影像学异常的无法得到组织学的证据,欧美国家回顾性研究CP发病率为3~9/10万,一项前瞻性研究提示发病率为8.2/10万,人群患病率为27.4/10万,我

Systemic inflammation contributes to impairment of quality of life in chronic pancreatitis复制标题

系统性炎症导致慢性胰腺炎患者的生活质量下降。

发表时间:2019-05-13

影响因子:4.0

作者: Robinson SM

期刊:Sci Rep

Chronic pancreatitis (CP) is a fibrotic disorder of the pancreas leading to clinical sequelae like pain  and an excess of comorbidity including cardiovascular disease and cancers. The aim of this study was to determine the relationship between systemic inflammation and quality of life in patients with CP. Patients were prospectively recruited and underwent a quality of life assessment (EORTC QLQ-C30 and PAN 28). The serum inflammatory profile was assessed using an MSD 30-plex array. The relationship between clinical variables, inflammatory cytokines and quality of life was determined by a GLMMANOVA and the individual impact of signifcant variables evaluated by a second ANOVA. In total, 211 patients with a median age of 53 years were recruited across 5 European centres. Gender, age, nicotine and alcohol abuse were clinical variables associated with altered quality of life. Systemic inflammation with high levels of pro-inflammatory cytokines (Eotaxin, IL-1β, IL-7, IL-8, IL-12/IL-23p40, IL-12p70, IL-13, IL-16, IP-10, MCP-1, MCP-4, MDC, MIP-1a, TARC, TNFß) was associated with diminished quality of life in general and specifc domains including pain, physical and cognitive functioning. As conclusion, CP is associated with a systemic inflammatory response that has a negative impact on quality of life and accelerates aging.

译文

慢性胰腺炎(CP)是胰腺的纤维化病症,导致临床后遗症如疼痛和包括心血管疾病和癌症在内的过多的合并症。本研究的目的是确定CP患者全身炎症与生活质量之间的关系。对患者进行前瞻性招募并进行生活质量评估(EORTC QLQ-C30和PAN 28)。使用MSD 30-plex阵列评估血清炎症谱。临床变量,炎性细胞因子和生活质量之间的关系由GLMMANOVA和通过第二ANOVA评估的显着变量的个体影响确定。总共有211名中位年龄为53岁的患者在5个欧洲中心招募。性别,年龄,尼古丁和酒精滥用是与生活质量改变相关的临床变量。伴有高水平促炎细胞因子的系统性炎症(嗜酸性粒细胞趋化因子,IL-1β,IL-7,IL-8,IL-12 / IL-23p40,IL-12p70,IL-13,IL-16,IP-10,MCP -1,MCP-4,MDC,MIP-1a,TARC,TNFβ)与一般生活质量下降和特定领域相关,包括疼痛,身体和认知功能。作为结论,CP与全身性炎症反应相关,其对生活质量具有负面影响并加速衰老。