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In search of stool donors: a multicenter study of prior knowledge, perceptions, motivators, and deterrents among potential donors for fecal microbiota transplantation.
寻找粪便供体: 一项关于粪便微生物移植潜在供体的先验知识、感知、动机和威慑的多中心研究。
Clostridioides difficile infection (CDI) Fecal microbiota transplantation (FMT) fecal transplant donors recurrent Clostridioides difficile infection (RCDI) stool donors
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摘要

Fecal microbiota transplantation (FMT) is a highly effective therapy for recurrent Clostridioides difficile infection. Stool donors are essential, but difficult to recruit and retain. We aimed to identify factors influencing willingness to donate stool. This multi-center study with a 32-item questionnaire targeted young adults and health care workers via social media and university email lists in Edmonton and Kingston, Canada; London and Nottingham, England; and Indianapolis and Boston, USA. Items included baseline demographics and FMT knowledge and perception. Investigated motivators and deterrents included economic compensation, screening process, time commitment, and stool donation logistics. Logistic regression and linear regression models estimated associations of study variables with self-assessed willingness to donate stool. 802 respondents completed our questionnaire: 387 (48.3%) age 21-30 years, 573 (71.4%) female, 323 (40%) health care workers. Country of residence, age and occupation were not associated with willingness to donate stool. Factors increasing willingness to donate were: already a blood donor (OR 1.64), male, altruism, economic benefit, knowledge of how FMT can help patients (OR 1.32), and positive attitudes towards FMT (OR 1.39). Factors decreasing willingness to donate were: stool collection unpleasant (OR 0.92), screening process invasive (OR 0.92), higher stool donation frequency, negative social perception of stool, and logistics of collection/transporting feces. We conclude that 1) blood donors and males are more willing to consider stool donation; 2) altruism, economic compensation, and positive feedback are motivators; and 3) screening process, high donation frequency, logistics of collection/transporting feces, lack of public awareness, and negative social perception are deterrents. Considering these variables could maximize donor recruitment and retention.

译文

粪便菌群移植 (FMT) 是一种治疗复发性艰难梭菌感染的高效疗法。粪便捐献者是必不可少的,但很难招募和留住。我们旨在确定影响捐赠粪便意愿的因素。这项多中心研究包含 32 项问卷调查,通过社交媒体和加拿大埃德蒙顿和金斯敦的大学电子邮件列表,以年轻人和卫生保健工作者为目标; 英国伦敦和诺丁汉; 美国印第安纳波利斯和波士顿。项目包括基线人口统计学和 FMT 知识和感知。调查的动机和威慑因素包括经济补偿、筛选过程、时间承诺和粪便捐赠物流。逻辑回归和线性回归模型估计了研究变量与自我评估的捐赠意愿的关联。802 名受访者完成了我们的问卷调查: 387 名 (48.3%) 年龄在 21-30 岁之间,573 名 (71.4%) 女性,323 名 (40%) 卫生保健工作者。居住国、年龄和职业与捐赠粪便的意愿无关。增加捐献意愿的因素有: 已经是一个献血者 (或 1.64) 、男性、利他主义、经济效益、关于 FMT 如何帮助病人的知识 (或 1.32) 、和对 FMT 的积极态度 (或 1.39)。减少捐赠意愿的因素有: 粪便收集不愉快 (或 0.92) 、筛选过程侵入性 (或 0.92) 、更高的粪便捐赠频率、负面的粪便社会感知, 以及收集/运输粪便的物流。我们的结论是 1) 献血者和男性更愿意考虑粪便捐赠; 2) 利他主义、经济补偿和正反馈是激励因素; 3) 筛选过程中,高捐赠频率, 收集/运输粪便的物流、缺乏公众意识和负面的社会观念是威慑。考虑到这些变量可以最大限度地增加捐助者的招募和保留。

fecal microbiota transplantation

消化 调节肠道菌群 治疗方法
概述  :  

粪菌移植(fecal microbiota transplantation,FMT)是将健康人粪便中的功能菌群通过一定方式移植至患者肠道内,从而调节紊乱的肠道菌群,重建具有正常功能的肠道微生态系统。目前FMT主要用于复发性难辨梭菌感染(Clostridium difficile infection,CDI)的治疗,在其他疾病中的应用亦不断有文献报道。   FMT的应用 FMT在复发性CDI中的应用:FMT已被纳入欧洲临床微生物学和传

fecal 英 /ˈfiːkl/  美 /ˈfiːkl/

释   义   adj. 排泄物的;残渣的;糟粕的

同根词   feces   n. feces 排泄物;渣滓

例    句   Her unique solution is not to get rid of wastewater and fecal sludge, but to value them. 她独特的解决办法不是排除废水,清理粪便和污泥,而是把这些东西重视起来。

 

microbiota 英 /,maɪkrəʊbvɪ'əʊtə/

释   义   n. 小型生物群,微生物区

例    句   Except no one is born with microbiota. It develops during the first year of life.  没有人生来就有微生物群,它是在婴儿生下来后第一年内形成的。

 

transplantation 英 /ˌtrænsplɑːnˈteɪʃn; ˌtrænzplɑːnˈteɪʃn/  美 /ˌtrænsplænˈteɪʃn,ˌtrænzplænˈteɪʃn/

释   义   n. 移植

例    句   Blood screening is vital to prevent infection through transfusion and organ transplantation. 血液筛检对预防通过输血和器官移植感染是至关重要的。

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