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hyponatremia

消化

关键词消化 疾病 水盐失衡

词汇介绍

拓展阅读

解析

hyponatremia  英 /,haipəunə'tri:miə/   美 /,haɪponə'trimiə/

释义   n. 低钠血症

例句   Drinking only water while you take part in high-energy athletic events can lead to acute hyponatremia. 当你参加高能耗体育活动时,只喝水的话会导致急性的低钠血症。

概述

低钠血症的定义为血清钠低于135mmol/L,为临床最常见的水盐失衡类型,其发生率约占住院患者的30%,因其涉及临床学科较广而备受临床医生的关注。 低钠血症的病理生理学分类根据低钠血症的病理生理学机制,可将其分类:(1)假性低钠血症。(2)非低渗性低钠血症:①等渗性低钠血症;②高渗性低钠血症。(3)低渗性低钠血症。1.假性低钠血症:正常血浆含7%容积的固相物质(即含水量为93%)。在实际检验时,为了减少所需血标本量,通常在检测前对血清标本进行稀释。因稀释仅对溶液的液相部分而言,固相

Weighing the prognostic role of hyponatremia in hospitalized patients with metastatic solid tumors: the HYPNOSIS study复制标题

转移性实体瘤住院患者低钠血症的预后评估: 催眠研究

发表时间:2019-09-10

影响因子:4.0

作者: Giovanni Fucà

期刊:Sci Rep

Hyponatremia, as defined by a serum sodium concentration lower than 135 mEg/L, is the electrolyte alteration most frequently found in hospitalized patients and a common finding at admission in Oncology Units2.In cancer patients, many overlapping factors can contribute to the onset of hyponatremia, including paraneoplastic syndromes(both cerebral salt wasting and syndrome of inappropriate antidiuretic hormone secretion, SIADH), clinical events (e.g. vomiting, diarrhea or bleeding) or syndromes (e., cachexia), anticancer treatments(cytotoxic agents, targeted therapies or immune checkpoint inhibitors) and general medications (e.g. opioids, diuretics and antidepressants). Albeit underdiagnos, SIADH is one of the most common causes of euvolemic hyponatremia, especially in patients with small cell lung cancer (SCLC). Non-small cell lung cancer(NSCLC),breast cancer(BC), head and neck cancer(HNC), and colorectal cancer(CRC)are the non-hematologic malignancies most frequently associated with hyponatremia.

译文

低钠血症(定义为血清钠浓度低于135 mEg / L)是住院患者中最常见的电解质改变,也是肿瘤科住院时的常见发现2.在癌症患者中,许多重叠因素均可导致低钠血症的发作包括副肿瘤综合征(脑盐消耗和抗利尿激素分泌异常综合征,SIADH),临床事件(例如呕吐,腹泻或出血)或综合征(例如恶病质),抗癌治疗(细胞毒剂,靶向疗法或免疫检查点)抑制剂)和一般药物(例如阿片类药物,利尿剂和抗抑郁药)。尽管诊断不足,但SIADH仍是葡萄球菌性低钠血症的最常见原因之一,尤其是在小细胞肺癌(SCLC)患者中。非小细胞肺癌(NSCLC),乳腺癌(BC),头颈癌(HNC)和结直肠癌(CRC)是与低钠血症最常见的非血液系统恶性肿瘤。