摘要

Photodynamic therapy (PDT) is an emerging theranostic modality for various cancers and diseases. The focus of this study was the development of tumor-targeting albumin nanoparticles containing photosensitizers for efficient PDT. To produce tumor-targeting albumin nanoparticles, the hydrophobic photosensitizer, chlorin e6 (Ce6), was chemically conjugated to human serum albumin (HSA). The conjugates formed self-assembled nanoparticle structures with an average diameter of 88 nm under aqueous conditions. As expected, the Ce6-conjugated HSA nanoparticles (Ce6-HSA-NPs) were nontoxic in their native state, but upon illumination with the appropriate wavelength of light, they produced singlet oxygen and damaged target tumor cells in a cell culture system. Importantly, when the nanoparticles were injected through the tail vein into tumor-bearing HT-29 mice, Ce6-HSA-NPs compared with free Ce6 revealed enhanced tumor-specific biodistribution and successful therapeutic results following laser irradiation. These results suggest that highly tumor-specific albumin nanoparticles have the potential to serve not only as efficient therapeutic agents, but also as photodynamic imaging (PDI) reagents in cancer treatment.

译文

光动力疗法 (PDT) 是一种治疗各种癌症和疾病的新兴疗法。本研究的重点是开发含有光敏剂的肿瘤靶向白蛋白纳米颗粒,用于高效 PDT。为了生产肿瘤靶向白蛋白纳米颗粒,疏水性光敏剂氯蛋白 e6 (Ce6) 与人血清白蛋白 (HSA) 化学结合。共轭物在水溶液条件下形成了平均直径为 88 nm 的自组装纳米粒子结构。不出所料,Ce6-conjugated 的 HSA 纳米粒子 (Ce6-HSA-NPs) 在它们的天然状态下是无毒的,但是在用合适波长的光照射时, 他们产生单线态氧,并在细胞培养系统中损坏目标肿瘤细胞。重要的是,当纳米粒子通过尾静脉注射到荷瘤 HT-29 小鼠体内时,与游离 Ce6 相比,Ce6-HSA-NPs 显示出增强的肿瘤特异性生物分布和激光照射后的成功治疗结果。这些结果表明,高度肿瘤特异性白蛋白纳米粒子不仅有潜力作为有效的治疗剂,而且在癌症治疗中也有可能作为光动力成像 (PDI) 试剂。

Human Albumin

消化 治疗或预防肝硬化 临床研究术语
概述  :  

在肝病学领域,白蛋白被普遍用于治疗或预防肝硬化的严重并发症,随机临床试验和荟萃分析已经表明其在预防大量放腹水之后循环功能障碍(PPCD)和自发性细菌性腹膜炎(SBP)所致肾衰竭以及与血管收缩剂联合用于治疗肝肾综合征(HRS)的疗效。   白蛋白分子的结构、代谢和性能 白蛋白是健康人体循环中的主要蛋白(35~50g/L),大约占血浆蛋白的50%,其由肝细胞合成,释放到循环中(约10~15g/天)。 白蛋白主要在肌肉、肝

human 英 /ˈhjuːmən/  美 /ˈhjuːmən/

释义   adj. 人的;人类的n. 人;人类

例句   The accident was caused by human error. 这一事故是人为错误造成的。

 

albumin 英 /'ælbjʊmɪn/  美 /æl'bjʊmɪn/

释义   n. [生化] 白蛋白,[生化] 清蛋白

例句   Healthy glomeruli keep blood protein (mainly albumin)—which is needed to maintain the right amount of fluid in your body—from seeping into your urine. 健康的肾小球会保留血液中的蛋白质从尿液中渗出(主要是白蛋白),这是维持体内适量液体所必需的。


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