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首页 > 医学词汇大全 > chemotherapy induced nausea and vomiting
chemotherapy induced nausea and vomiting

消化

关键词消化 临床研究术语 化疗副反应

词汇介绍

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解析

chemotherapy 英 /ˌkiːməʊˈθerəpi/  美 /ˌkiːmoʊˈθerəpi/

释义   n. [临床] 化学疗法

例句   "There was no chemotherapy back then, only the knife, " she said. 她说:“那时还没有什么化学疗法,只能动手术。”

 

induced 英 /ɪn'djuːst/  美 /ɪn'djʊst/

释义   v. 引诱;说服(induce的过去分词) adj. 感应的;诱发

例句   The vascular wall stress is of great importance in the vascular remodeling process induced either by the change of blood flow or by hypertension. 无论是由血液流量改变或是由高血压引起的血管重建,血管壁上的应力都起着至关重要的作用。

 

nausea 英 /ˈnɔ:ziə/  美 /ˈnɔːziə,ˈnɔːsiə/

释义   n. 恶心,晕船;极端的憎恶

例句   I have headache, nausea and diarrhea. 我头痛,恶心,还有腹泻。

 

vomiting  英 /'vɔmitiŋ/   美 /'vɑmɪt/

释义   v. 呕吐(vomit的ing形式)

例句   Never prepare food for others if you have diarrhea or vomiting. 如果你腹泻或呕吐,千万不要为他人准备食物。


概述

化疗所致恶心呕吐(CINV)是肿瘤治疗过程中常见的并发症之一,处理不当将对患者后续治疗及疾病转归造成严重影响。化疗所致的恶心呕吐是因化疗药物导致的恶心呕吐反应。按照发生时间的不同,CINV可分为5类:急性、延迟性、预期性、爆发性及难治性急性呕吐。急性呕吐发生在初次化疗后24小时以内,迟发型呕吐则在初次化疗后几天发生。 止吐药的分类简介1. 多巴胺受体抑制剂,代表药物有甲氧氯普胺、多潘立酮,因其能够促进泌乳素分泌而不适用于乳腺癌患者。2. NK-1受体抑制剂,已经

Single center experience on efficacy and safety of Aprepitant for preventing chemotherapy-induced nausea and vomiting (CINV) in pediatric Hodgkin Lymphoma复制标题

阿瑞匹坦预防小儿霍奇金淋巴瘤化疗所致恶心呕吐 (CINV) 的疗效和安全性的单中心经验

发表时间:2019-04-12

影响因子:2.8

作者: Giovanna Giagnuolo

期刊:PLoS ONE

The combination of corticosteroid and serotonin receptor antagonists (5-HT3-RAs) has been the gold standard of CINV prevention related to highly(HEC) and moderately emetogenic chemotherapy (MEC), until the introduction of Aprepitant , a selective neurokinin-1(NK-1) receptor antagonist that, with its long lasting, central and peripheral, antiemetic activity, has provided a significant improvement in control of both acute and delayed CINV, with considerable benefits on treatment compliance. In 2013, the Pediatric Oncology Group of Ontario(POGO) Guidelines recommended that children scheduled for HEC should be administered antiemetic prophylaxis of ondansetron plus dexamethasone with or without aprepitant; however, this recommendation applied only to children aged >12 years.

译文

皮质类固醇和5-羟色胺受体拮抗剂(5-HT3-RAs)的组合已成为预防CINV的金标准,与高度(HEC)和中度致呕性化疗(MEC)有关,直到引入选择性神经激肽1(NK)之前 -1)受体拮抗剂,具有持久的中枢和外周止吐活性,在控制急性CINV和延迟CINV方面均取得了显着改善,对治疗依从性有显着益处。 2013年,《安大略省儿科肿瘤学小组指南》建议对计划进行HEC的儿童进行恩丹西酮加地塞米松联合或不联合阿雷替丁的止吐预防; 但是,此建议仅适用于12岁以上的儿童。