gut-brain axis microbiota prebiotics probiotics psychiatric disorders
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摘要

CONTEXT:The gut-brain axis and microbial dysbiosis may play a role in psychiatric diseases. In this view, the gut microbiota has been considered a potential therapeutic target using probiotics and prebiotics.
OBJECTIVE:This systematic review aims to find the existing clinical evidence that may justify the use of probiotics or prebiotics in psychiatric patients.
DATA SOURCES:PRISMA guidelines were followed for a systematic literature review of randomized controlled trials that assessed the effect of prebiotics or probiotics in patients diagnosed with a classified psychiatric disorder.
DATA EXTRACTION:From a total of 212 studies screened, 11 were included in the final systematic review. Quality assessment of the included trials was assessed by the Jadad scale.
RESULTS:Probiotics seem to offer some benefit in major depressive disorder and Alzheimer's disease. One study showed that probiotics reduced rehospitalization in patients with acute mania. In autism spectrum disorders, the results were controversial; however a single study found that early administration of probiotics showed a preventive role. No benefits were found for patients with schizophrenia. In most studies, no major adverse effects were reported.
CONCLUSIONS:Although recent findings in specific psychiatric disorders are encouraging, the use of prebiotics and probiotics in clinical practice stills lacks sufficiently robust evidence.

译文

背景: 肠脑轴和微生物生态失调可能在精神疾病中发挥作用。在这种观点下,肠道菌群被认为是使用益生菌和益生元的潜在治疗目标。
目的: 本系统综述旨在寻找现有的临床证据,证明在精神病患者中使用益生菌或益生元是合理的。
数据来源: 遵循 PRISMA 指南,对随机对照试验进行系统文献综述,评估益生元或益生菌对诊断为分类精神疾病患者的影响。
数据提取: 从总共筛选的 212 项研究中,11 项被纳入最终的系统综述。采用 Jadad 量表对纳入的试验进行质量评估。
结果: 益生菌似乎对重度抑郁症和阿尔次海默病有一些益处。一项研究表明,益生菌减少了急性躁狂症患者的再住院治疗。在自闭症谱系障碍中,结果是有争议的; 然而,一项单一的研究发现,益生菌的早期给药显示了预防作用。没有发现精神分裂症患者的益处。在大多数研究中,没有主要副作用的报道。
结论: 尽管最近在特定精神疾病中的发现令人鼓舞,但在临床实践中使用益生元和益生菌仍然缺乏足够有力的证据。

probiotics

消化 胃肠道疾病 药物
概述  :  

特定的益生菌可以减轻肠易激综合症患者的胃肠道症状,预防由抗生素和幽门螺杆菌根除治疗引发的腹泻,并显示了良好的安全性。采⽤益⽣菌可以治疗或预防下消化道症状。包括腹痛、腹泻、腹胀、便秘等一系列问题,原因复杂,异质性较强,临床医师常感到药物选择困难,因为目前还没有哪种单一药物治疗对所有情况均有效。近年来,随着对肠道菌群在人类疾病中重要性认识的不断深入,越来越多的研究者开始尝试采用益生菌治疗肠道疾病,如肠易激综合征(IBS)等。益生菌的作用机制包括竞争性排斥病原微生物、抑制病原体黏附、增强肠黏膜屏障

probiotics /prəbai'ɔtiks/

释义   n. 益生菌;促生素或益菌

例句   Probiotics what I have seen, but I do not know on the suitability of my children.我所看到的益生菌,但我不知道是否适合我的孩子。


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