释义 n. 甘草甜素；甘草酸
例句 Purpose to investigate the effects and binding sites of glycyrrhetinic acid and glycyrrhizin on isolated rat hepatocyte membrane.目的研究甘草次酸和甘草酸对离体大鼠肝细胞膜的作用及其结合位点。
acid 英 /ˈæsɪd/ 美 /ˈæsɪd/
释义 n. 酸
例句 He treats this substance with the acid more carefully than before.他比以前更小心地用酸来处理这种物质。
作者： Yukihiro Yoshida
The enzyme kynurenine aminotransferase(KAT) catalyses the conversion of kynurenine(KYN) to kynurenic acid(KYNA). Although the isozymes KAT1-4 have been identified, KYNA is mainly produced by KAT2 in brain tissues. KNYA is an antagonist of N-methyl-D-aspartate and α-7-nicotinic acetylcholine receptors, and accumulation of KYNA in the brain has been associated with the pathology of schizophrenia. Therefore, KAT2 could be exploited as a therapeutic target for the management of schizophrenia. Although currently available KAT2 inhibitors irreversibly bind to pyridoxal 5-phosphate (PLP), inhibition via this mechanism may cause adverse side effects because of the presence of other PLP-dependent enzymes. Therefore, we identified novel selective KAT2 inhibitors by screening approximately 13,000 molecules. Among these, glycyrrhizic acid(GL)and its analogues, glycyrrhetinic acid(GA)and carbenoxolone(CBX), were identified as KAT2 inhibitors.