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Glycyrrhizic acid, active component from Glycyrrhizae radix, prevents toxicity of graphene oxide by influencing functions of microRNAs in nematode Caenorhabditis elegans.
甘草酸是甘草的活性成分,通过影响线虫中 microRNAs 的功能来防止氧化石墨烯的毒性。
Caenorhabditis elegans Glycyrrhizae radix Glycyrrhizic acid Graphene oxide MicroRNAs Nanotoxicity Prevention
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摘要

UNLABELLED:We investigated effects of pretreatment with Glycyrrhizae radix (GR) or its specific components on toxicity of graphene oxide (GO) in Caenorhabditis elegans. GR pretreatment prevented GO toxicity on function of both primary and secondary targeted organs. Among active components in GR, the beneficial effects of GR were attributable to presence of glycyrrhizic acid. Glycyrrhizic acid pretreatment suppressed translocation of GO into secondary targeted organs through intestinal barrier. Glycyrrhizic acid pretreatment recovered expression patterns of dysregulated microRNAs (miRNAs) induced by GO, and genes required for oxidative stress control acted as targeted genes for some of these miRNAs. Among these miRNAs, mir-360 mutation enhanced beneficial effects of glycyrrhizic acid. We hypothesize that glycyrrhizic acid may prevent GO toxicity and translocation by influencing functions of miRNAs which upstream regulate functions of their targeted genes. Furthermore, glycyrrhizic acid had potential to extend lifespan, and to suppress accelerated aging process induced by GO.
FROM THE CLINICAL EDITOR:Exposure to graphene oxide may pose toxic effects to health, as suggested in animal studies. In this article, the authors showed that the use of glycyrrhizae radix (GR) prevented toxicity of graphene oxide in Caenorhabditis elegans. These results may provide novel strategies in the reducing potential side effects of nanoparticles.

译文

未标记: 我们研究了甘草 (GR) 或其特定成分预处理对秀丽隐杆线虫中氧化石墨烯 (GO) 毒性的影响。GR 预处理可防止 GO 对一级和二级靶器官功能的毒性。在 GR 的活性成分中,GR 的有益作用归因于甘草酸的存在。甘草酸预处理抑制 GO 通过肠屏障进入二级靶器官。甘草酸预处理恢复了 GO 诱导的失调 microRNAs (miRNAs) 的表达模式,氧化应激控制所需的基因作为其中一些 miRNAs 的靶向基因。在这些 miRNAs 中,mir-360 突变增强了甘草酸的有益作用。我们假设甘草酸可能通过影响上游调节其靶基因功能的 miRNAs 的功能来阻止 GO 毒性和易位。此外,甘草酸具有延长寿命和抑制 GO 诱导的加速衰老过程的潜力。
来自临床编辑: 正如动物研究所表明的,接触氧化石墨烯可能对健康造成毒性影响。在这篇文章中,作者表明使用甘草 (GR) 可以防止秀丽隐杆线虫中氧化石墨烯的毒性。这些结果可能为减少纳米粒子的潜在副作用提供新的策略。

Glycyrrhizic acid

消化 肝病治疗 药物
概述  :  

甘草酸(glycyrrhizic acid,AG)为五环三萜类化合物,其分子式C42H62O16,分子量为822.92,以18α和18β两种立体异构体形式存在。不同甘草酸制剂作用机制基本一致,均具有明确的抗炎和保肝等作用。 治疗机制高迁移率蛋白族1(high mobility group box-1,HMGB1)是目前研究较多的一种炎症通路上游调控因子。一般认为HMGB1是一种高度保守的蛋白,能够在各种细胞中表达,受激发后作为损伤关联分子模式(DAMP)分子被释放到细胞外,从而激活

glycyrrhizin 

释义   n. 甘草甜素;甘草酸

例句   Purpose to investigate the effects and binding sites of glycyrrhetinic acid and glycyrrhizin on isolated rat hepatocyte membrane.目的研究甘草次酸和甘草酸对离体大鼠肝细胞膜的作用及其结合位点。

 

acid 英 /ˈæsɪd/ 美 /ˈæsɪd/

释义   n. 酸

例句   He treats this substance with the acid more carefully than before.他比以前更小心地用酸来处理这种物质。


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