gallstone 英 /ˈɡɔːlstəʊn/ 美 /ˈɡɔːlstoʊn/
释义 n. 胆石；胆结石
例句 Gallstone:Mass of crystallized substances that forms in the gallbladder. 胆石：在胆囊形成的大量晶体化物质。
作者： Helene Gellert-Kristensen
Gallstone disease is a common complex disease that confers a substantial economic burden on society. The genetic underpinnings of gallstone disease remain incompletely understood. We aimed to identify new genetic associations with gallstone disease using publicly available data from the UK Biobank and two large Danish cohorts. We extracted genetic associations with gallstone disease from the Global Biobank Engine(GBE), an online browser of genomewide associations in UK Biobank participants(14,940 cases and 322,268 controls). Significant associations (P-<5x10-8) were retested in two Copenhagen cohorts(comprising 1,522 cases and 18,266 controls). In the Copenhagen Cohorts, we also tested whether a genetic risk score associated with gallstone disease, and whether individual gallstone loci were associated with plasma levels of lipids, lipoproteins, and liver enzymes. We identified 19 loci to be associated with gallstone disease in the GBE. Of these, 12 were replicated in the Copenhagen cohorts, including six previously unknown( in HNF4A, FUT2, SERPINAI, JMIDIC, AC074212.3, and SLCI0A2), and six known loci (in ABCG8, SULT2A1, CYP7A1, TM4SF4, ABCB4, and TTC39B).