Chronic 英 /ˈkrɒnɪk/ 美 /ˈkrɑːnɪk/
例句 In some people, constipation is chronic and can last 12 weeks or more. 有些人的便秘是慢性的，可以持续12周或者更长。
constipation 英 /ˌkɒnstɪˈpeɪʃn/ 美 /ˌkɑːnstɪˈpeɪʃn/
释义 n. [临床] 便秘；受限制
例句 Do you have trouble with constipation. 你有便秘的困扰吗？
作者： Alicia Gilsenan
Chronic constipation is a common and often debilitating medical problem, with an impact on quality of life. The 5-hydroxytryptamine (serotonin) receptor type 4 (5-HT4) receptor agonists have the potential to treat disorders of gastrointestinal motility, including delayed gastric emptying and colonic dysmotility. The frst-generation 5-HT4 receptor agonists cisapride and tegaserod were with drawn from the US market because of serious concerns about associated cardiovascular risk, arrythmias thought to be associated with QTc prolongation with cisapride, and ischemic events of uncertain origin with tegaserod. Prucalopride, a selective 5-HT4 agonist with high affinity and selectivity for the 5-HT4 receptors, has been licensed in the European Union since 2009 for adult women and since 2015 for adult men for the treatment of chronic constipation and is currently approved in 82 countries. No signal for an increased risk of adverse cardiovascular events or QTc prolongation has been observed for prucalopride during non-clinical and clinical cardiovascular investigations or as a result of safety monitoring.