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首页 > 医学词汇大全 > acute liver failure
acute liver failure

消化

关键词消化 疾病 肝功能损害

词汇介绍

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解析

acute 英 /əˈkjuːt/  美 /əˈkjuːt/

释义   adj. 严重的,[医] 急性的;敏锐的;激烈的;尖声的

例句   But in other situations, a liver transplant may be the only cure for acute liver failure. 但是在其他情况下,肝脏移植可能是急性肝衰竭的唯一治愈希望。

 

liver 英 /ˈlɪvə(r)/  美 /ˈlɪvər/

释义   n. 肝脏;生活者,居民

例句   Three weeks ago, it was discovered the cancer had spread to his liver. 三周前,发现癌细胞已扩散到了他的肝脏。

 

failure 英 /ˈfeɪljə(r)/  美 /ˈfeɪljər/

释义   n. 失败;故障;失败者;破产

例句   There were also several accidents mainly caused by engine failures on take-off.

还有一些事故主要是由起飞时引擎故障导致的。


概述

急性肝衰竭(acute liver failure)多是由药物、肝毒性物质、病毒、酒精等因素诱发的一组临床综合征,病人肝功能急剧恶化,表现为意识障碍和凝血功能紊乱等,多见于中青年人,发病迅速病死率高。 病因和发病机制病因:在我国,引起肝衰竭的首要因素是乙型肝炎病毒,其引起的慢加急性(亚急性)肝衰竭最为常见。其他常见病因包括药物性肝损伤、病毒性肝炎、自身免疫性肝病及休克或低血压引起的缺血性肝损伤。然而仍有约15%的患者病因不明。 发病机制:涉及内毒素及细胞因子介导的免疫炎症损伤,肝微循环障碍,

A Faux Case of Acute Liver Failure in a 28-Year-Old Pregnant Woman.复制标题

一个虚假的急性肝衰竭28岁的孕妇.

发表时间:2018-07-10

影响因子:15.0

作者: Morgan H Randall

期刊:Hepatology

This patient was particularly noteworthy for several reasons. First, she had a previous history of "ALF", though it was extremely unusual in that she was taken to the operating room, but not transplanted. Secondly, she presented with an identical clinical syndrome during pregnancy during the current admission. Pregnancy associated liver diseases were particularly important to consider in this patient, but none of these fit the clinical picture. With her alteration in mental status, there was concern about the possibility of AFLP, but this typically presents later in pregnancy and the laboratory data did not fi this diagnosis. Additionally, her platelets were normal, making HELLP unlikely. Given that she had a similar episode in the past, there was concern about possible recurrent seronegative autoimmune hepatitis, making a liver biopsy important diagnostically. Liver histology excluded significant liver injury, and helped point to a diagnosis of a UCD.

译文

该患者特别值得注意,原因有几个。 首先,她曾经有过“ ALF”病史,尽管这是非常不寻常的,因为她被带到手术室,但没有被移植。 其次,在当前入院期间,她在怀孕期间出现了相同的临床综合征。 在该患者中考虑与妊娠相关的肝病尤为重要,但这些都不符合临床情况。 由于她的心理状态发生了改变,人们担心AFLP的可能性,但是这种情况通常在妊娠后期出现,实验室数据并未对此做出诊断。 此外,她的血小板正常,因此不太可能帮助她。 考虑到她过去有类似的发作,人们担心可能会出现血清阴性的自身免疫性肝炎复发,这使得肝活检在诊断上很重要。 肝组织学排除了严重的肝损伤,并有助于指出UCD的诊断。