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首页 > 医学词汇大全 > Prolyl Hydroxylase
Prolyl Hydroxylase

消化

关键词消化 临床研究术语 肝纤维化

词汇介绍

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解析

prolyl 英 [p'rɒlɪl] 美 [p'rɒlɪl]

释义   n. [生化] 脯氨酰;脯氨酰基

例句   Method: By the international literature, the structure-activity relationships of prolyl oligopeptidase inhibitors, natural active constituents, and clinical studies were summed up. 方法:根据国外相关文献,对脯氨酰寡肽酶抑制剂的构效关系、天然活性成分以及临床试验情况进行整理和归纳。

 

hydroxylase 英 [haɪ'drɒksɪleɪs] 美 [haɪ'drɒksɪleɪs]

释义   n. [生化] 羟化酶

例句   Objective: Clinical data of 19 Chinese patients with 21 hydroxylase deficiency (21OHD) were analyzed to improve the diagnosis and treatment level. 目的:分析19例21羟化酶缺陷症(21OHD)患者的临床和随访资料,提高该病的诊断和治疗水平。


概述

脯氨酰羟化酶(prolyl hydroxylase,PH)是胶原纤维合成酶,是肝纤维化的生化指标之一。肝脏纤维化胶原纤维合成亢进时,肝组织中及血清中PH活性均增高。 检测方法放射免疫法(RIA)。 正常值(20.8-58.2)μg/L。各实验室应建立自己适合的参考区间。 临床意义与评价用于肝脏纤维化的诊断、随访及预后判断。肝脏纤维化及伴有纤维化的肝脏病变时PH活性增高,如:(1)肝硬化及血吸虫性肝纤维化,PH明显增高;(2)原发性肝癌(多伴有肝硬化)PH增高,转

Depletion of Endothelial Prolyl Hydroxylase Domain Protein 2 and 3 Promotes Cardiomyocyte Proliferation and Prevents Ventricular Failure Induced by Myocardial Infarction复制标题

内皮脯氨酰羟化酶结构域蛋白2和3的耗竭促进心肌细胞增殖并预防心肌梗死引起的心室衰竭

发表时间:2019-07-30

影响因子:23.1

作者: Aude Angelini

期刊:Circulation

Maintaining oxygen homeostasis is essential for the survival of aerobic living  creatures. Inadequate supply of oxygen plays central roles in the pathogenesis of myocardial infarction (MI), stroke, and cancers. On the other hand, moderate hypoxia can also trigger a series of adaptive responses such as erythropoiesis and angiogenesis. The evolutionarily conserved prolyl hydroxylase domain protein (PHD)–hypoxia-inducible factor pathway plays pivotal roles in these processes.1 Hypoxia can also induce cardiomyocyte proliferation and heart regeneration in adult mice.2 However, the underlying mechanisms remain elusive. From an anatomic perspective, the heart is a highly organized pluricellular organ and composed of 4 major cell types: cardiomyocytes, endothelial cells (ECs), smooth muscle cells, and fibroblasts. In particular, vascular ECs, which act as the “first responder” to environmental cues such as oxygen and nutrients, not only control vascular permeability but also maintain cardiac function by releasing various secreted factors. However, whether the interaction between ECs and cardiomyocytes is involved in cardiomyocyte proliferation remains unexplored.

译文

维持氧气稳态对于有氧生物的生存至关重要。氧气供应不足在心肌梗死(MI),中风和癌症的发病机理中起着重要作用。另一方面,中度缺氧也可以引发一系列适应性反应,例如红细胞生成和血管生成。进化上保守的脯氨酰羟化酶结构域蛋白(PHD)-缺氧诱导因子途径在这些过程中起着关键作用。1缺氧还可以诱导成年小鼠的心肌细胞增殖和心脏再生。2然而,其潜在机制仍然难以捉摸。从解剖学角度来看,心脏是高度组织化的多细胞器官,由4种主要细胞类型组成:心肌细胞,内皮细胞(EC),平滑肌细胞和成纤维细胞。尤其是,作为对环境线索(例如氧气和养分)的“第一响应者”的血管内皮细胞不仅控制血管渗透性,而且通过释放各种分泌因子来维持心脏功能。然而,ECs和心肌细胞之间的相互作用是否参与了心肌细胞的增殖尚待探讨。