prolyl 英 [p'rɒlɪl] 美 [p'rɒlɪl]
释义 n. [生化] 脯氨酰；脯氨酰基
例句 Method: By the international literature, the structure-activity relationships of prolyl oligopeptidase inhibitors, natural active constituents, and clinical studies were summed up. 方法：根据国外相关文献，对脯氨酰寡肽酶抑制剂的构效关系、天然活性成分以及临床试验情况进行整理和归纳。
hydroxylase 英 [haɪ'drɒksɪleɪs] 美 [haɪ'drɒksɪleɪs]
释义 n. [生化] 羟化酶
例句 Objective: Clinical data of 19 Chinese patients with 21 hydroxylase deficiency (21OHD) were analyzed to improve the diagnosis and treatment level. 目的：分析19例21羟化酶缺陷症（21OHD）患者的临床和随访资料，提高该病的诊断和治疗水平。
作者： Aude Angelini
Maintaining oxygen homeostasis is essential for the survival of aerobic living creatures. Inadequate supply of oxygen plays central roles in the pathogenesis of myocardial infarction (MI), stroke, and cancers. On the other hand, moderate hypoxia can also trigger a series of adaptive responses such as erythropoiesis and angiogenesis. The evolutionarily conserved prolyl hydroxylase domain protein (PHD)–hypoxia-inducible factor pathway plays pivotal roles in these processes.1 Hypoxia can also induce cardiomyocyte proliferation and heart regeneration in adult mice.2 However, the underlying mechanisms remain elusive. From an anatomic perspective, the heart is a highly organized pluricellular organ and composed of 4 major cell types: cardiomyocytes, endothelial cells (ECs), smooth muscle cells, and fibroblasts. In particular, vascular ECs, which act as the “first responder” to environmental cues such as oxygen and nutrients, not only control vascular permeability but also maintain cardiac function by releasing various secreted factors. However, whether the interaction between ECs and cardiomyocytes is involved in cardiomyocyte proliferation remains unexplored.