消化
词汇介绍
拓展阅读
解析
prolyl 英 [p'rɒlɪl] 美 [p'rɒlɪl]
释义 n. [生化] 脯氨酰;脯氨酰基
例句 Method: By the international literature, the structure-activity relationships of prolyl oligopeptidase inhibitors, natural active constituents, and clinical studies were summed up. 方法:根据国外相关文献,对脯氨酰寡肽酶抑制剂的构效关系、天然活性成分以及临床试验情况进行整理和归纳。
hydroxylase 英 [haɪ'drɒksɪleɪs] 美 [haɪ'drɒksɪleɪs]
释义 n. [生化] 羟化酶
例句 Objective: Clinical data of 19 Chinese patients with 21 hydroxylase deficiency (21OHD) were analyzed to improve the diagnosis and treatment level. 目的:分析19例21羟化酶缺陷症(21OHD)患者的临床和随访资料,提高该病的诊断和治疗水平。
概述
概述
脯氨酰羟化酶(prolyl hydroxylase,PH)是胶原纤维合成酶,是肝纤维化的生化指标之一。肝脏纤维化胶原纤维合成亢进时,肝组织中及血清中PH活性均增高。
检测方法
放射免疫法(RIA)。
正常值
(20.8-58.2)μg/L。各实验室应建立自己适合的参考区间。
临床意义与评价
用于肝脏纤维化的诊断、随访及预后判断。肝脏纤维化及伴有纤维化的肝脏病变时PH活性增高,如:
(1)肝硬化及血吸虫性肝纤维化,PH明显增高;
(2)原发性肝癌(多伴有肝硬化)PH增高,转移性肝癌PH正常;
(3)急性肝炎及轻型慢性肝炎PH多数正常,如肝坏死加重并出现胶原纤维合成亢进,则PH增高;
(4)中、重度慢性肝炎PH增高;
(5)PH活性增高与肝细胞坏死及纤维化程度平行,慢性肝炎、肝硬化病人如PH进行性增高,提示肝细胞坏死和纤维化加重,如治疗后PH逐渐下降,提示治疗有效,病情好转。
内皮脯氨酰羟化酶结构域蛋白2和3的耗竭促进心肌细胞增殖并预防心肌梗死引起的心室衰竭
发表时间:2019-07-30
影响指数:23.1
作者: Aude Angelini
期刊:Circulation
Maintaining oxygen homeostasis is essential for the survival of aerobic living creatures. Inadequate supply of oxygen plays central roles in the pathogenesis of myocardial infarction (MI), stroke, and cancers. On the other hand, moderate hypoxia can also trigger a series of adaptive responses such as erythropoiesis and angiogenesis. The evolutionarily conserved prolyl hydroxylase domain protein (PHD)–hypoxia-inducible factor pathway plays pivotal roles in these processes.1 Hypoxia can also induce cardiomyocyte proliferation and heart regeneration in adult mice.2 However, the underlying mechanisms remain elusive. From an anatomic perspective, the heart is a highly organized pluricellular organ and composed of 4 major cell types: cardiomyocytes, endothelial cells (ECs), smooth muscle cells, and fibroblasts. In particular, vascular ECs, which act as the “first responder” to environmental cues such as oxygen and nutrients, not only control vascular permeability but also maintain cardiac function by releasing various secreted factors. However, whether the interaction between ECs and cardiomyocytes is involved in cardiomyocyte proliferation remains unexplored.
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