消化
词汇介绍
拓展阅读
解析
monoamine 英 [,mɒnəʊ'eɪmiːn]
释义 n. [有化] 一元胺;单胺,单胺类
例句 Objective: To study the effect of subhypothermia and hypoxia on the contents of brain monoamine neurotransmitters and serum electrolyte. 目的:研究亚低温低压缺氧对大鼠脑单胺类神经递质含量和血清电解质水平的影响。
oxidase 英 ['ɒksɪdeɪz]
释义 n. [生化] 氧化酶
例句 Glucose oxidase consumes oxygen in the process of glucose oxidation. 葡萄糖氧化酶在氧化葡萄糖的过程中消耗氧。
概述
概述
单胺氧化酶(monoamine oxidase,MAO)为反映肝纤维化的酶,可分为两类。一类存在于肝、肾等组织的线粒体中,以FAD为辅酶,参与儿茶酚胺的分解代谢。另一类存在于结缔组织,是一种细胞外酶,无FAD而含有磷酸吡哆醛,只对伯胺起作用。血清中MAO和结缔组织中的MAO性质相似,能促进结缔组织的成熟,参与胶原成熟最后阶段架桥形成,使胶原与弹性硬蛋白结合。广泛分布于肝、肾、胃、小肠和脑等组织。肝脏MAO存在于线粒体中,少量存在于细胞质可溶成分中。
检测方法
比色法与速率法(多用)。
参考值
比色法12000~40000UL(12~40uUml);速率法(37℃)0~3UL。不同方法测定结果有差异,各实验室应验证所引用参考区间或建立本实验室的适宜参考区间。
临床意义与评价
临床上单胺氧化酶的偏高,主要分为生理性升高和病理性升高。生理性升高主要是由于长期熬夜、紧张刺激、饮食习惯、睡眠障碍引起。调整作息时间避免紧张刺激,进清淡饮食,按时休息可以恢复正常。
病理性升高主要用于诊断肝硬变。
1)重症肝硬化及肝硬化伴肝癌时,明显增高(其活性增高与肝脏纤维化程度呈正相关);
2)暴发性重症肝炎时MAO明显升高,一般急性肝炎和慢性肝炎轻度时MAO正常,慢性肝炎中、重度时MAO增高占50%;
3)严重脂肪肝时可增高;
4)其他疾病:甲状腺功能亢进、糖尿病、肢端肥大症、结缔组织病、慢性充血性心力衰竭肝淤血时亦可见增高。
Monoamine oxidase A inhibition by toxic concentrations of metaxalone复制标题
毒性浓度的单胺氧化酶A抑制
发表时间:2019-08-01
影响指数:4.4
作者: Brett Cherrington
期刊:Clinical Toxicology
Serotonin toxicity is a severe adverse event associated with serotonergic drugs resulting from excessive serotonergic activity in the central nervous system (CNS). It most frequently occurs following the use of multiple serotonergic drugs, although it is also described after therapeutic dosing or overdoses of single serotonergic drugs as well [1–3]. Numerous drugs and drug combinations are associated with serotonin toxicity, for instance, monoamine oxidase inhibitors (MAOIs), serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, opioid analgesics, etc. Excess serotonin produces a spectrum of clinical findings ranging from mild symptoms to fatality. Clinical manifestations are classically characterized as the triad of altered mental status, autonomic instability, and neuromuscular abnormalities. Patients may present with one or more of these findings [2].
译文