摘要

Follicular lymphoma (FL) is one of the most frequently diagnosed lymphomas in the United States and Europe. The definition of and basic approach to diagnosis and grading of FL is essentially unchanged in the recently updated revision of the World Health Organization (WHO) classification. FL is a biologically and histopathologically heterogeneous disease. Although there is an improved understanding of some FL variants and specific subtypes, there are cases whose recognition is particularly challenging, either because they have unusual features or represent examples of new or rare variants. Herein, we share a series of unusual and difficult to recognize FLs with the goal of increasing awareness of the expanding histopathologic variability in FL. Unusual FL discussed here include: FL with Castleman-like changes, FL with plasmacytic differentiation, and immunoglobulin G4-positive plasma cells in the setting of immunoglobulin G4-related disease, FL with marginal zone differentiation and involving mucosa-associated lymphoid tissue sites, diffuse FL variant expressing CD23 with STAT6 mutation, large B-cell lymphoma with IRF4 rearrangement, CD10-negative and MUM1-positive aggressive FL, and Epstein-Barr virus-positive FL.

译文

滤泡性淋巴瘤 (FL) 是美国和欧洲最常诊断的淋巴瘤之一。FL 诊断和分级的定义和基本方法在最近更新的世卫组织分类修订中基本没有改变。FL 是一种生物学上和组织病理学上的异质性疾病。虽然对一些 FL 变异和特定亚型的理解有所提高,但有些病例的识别特别具有挑战性,要么是因为它们具有不寻常的特征,要么是因为它们代表了新的或罕见变异的例子。在此,我们分享了一系列不寻常且难以识别的 FLs,目的是提高对 FL 中不断扩大的组织病理学变异性的认识。这里讨论的不寻常的 FL 包括: 具有 Castleman 样变化的 FL,具有浆细胞溶解分化的 FL,以及免疫球蛋白 G4-positive 疾病背景下的浆细胞 G4-related 免疫球蛋白, FL 与边缘区分化并涉及粘膜相关淋巴组织部位,弥漫 FL 变异表达 CD23 与 STAT6 突变,大 b细胞淋巴瘤与 IRF4 重排,CD10-negative 和 MUM1-positive 侵袭性 FL,以及 Epstein-Barr 病毒阳性 FL。

Follicular Lymphoma

消化 非霍奇金淋巴瘤 疾病
概述  :  

滤泡性淋巴瘤(follicular lymphoma,FL)在全世界占非霍奇金淋巴瘤(Non-Hodgkin lymphoma, NHL)的22%。滤泡性淋巴瘤患者一般发病年龄较大,多见于50岁以上的患者。在疾病得到诊断时,病变累及的范围已较广泛,除淋巴结病变外,常有脾脏和骨髓累及。尽管如此,这类患者的中位生存时间仍可达 8~12年,因而,滤泡性淋巴瘤被认为属于惰性淋巴瘤的范畴。约90%的患者具有Bcl-2基因重排。 典型症状滤泡性淋巴瘤最常见的表现是无痛性淋巴结肿大,典型表现为多

follicular  [fə'lɪkjəlɚ]

释义   adj. 滤泡的;卵泡的;小囊的

例句   Objective:To apply in vitro maturation (IVM) to poor responding of ovary and retardation of follicular development during conventional in vitro fertilization (IVF) cycle. 目的:探讨利用未成熟卵体外成熟技术治疗卵巢反应不良和卵泡发育迟缓周期的可能性。

 

lymphoma 英 [lɪmˈfəʊmə] 美 [lɪmˈfoʊmə]

释义   n. [肿瘤] 淋巴瘤

复数 lymphomas或lymphomata

例句   Methods:To apply the position plate for position and set-up during the Lymphoma irradiation, and compare the effects with the traditional method.  方法:以恶性淋巴瘤为例,放疗过程中应用定位模板进行定位、复位、摆位,同时和传统的方法进行比较。


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