摘要

PURPOSE:Enteropathy-associated T-cell lymphoma (EATL) is a rare intestinal non-Hodgkin lymphoma with a poor, though variable prognosis. The International Prognostic Index (IPI) and the prognostic index for peripheral T-cell lymphoma (PIT) have limited predictive value for outcome of EATL. The purpose of this study was to develop and validate a prognostic model for EATL, which can identify high-risk patients who need more aggressive therapy.
EXPERIMENTAL DESIGN:This retrospective multicenter study was based on 92 patients and included 45 patients diagnosed with EATL between 1999 and 2009 from the Netherlands and 47 patients from England and Scotland, diagnosed with EATL between 1994 and 1998. A new EATL prognostic index (EPI) was constructed using the RPART (recursive partitioning and regression trees) procedure. Validation was performed applying the bootstrap method.
RESULTS:Three risk groups were distinguished (P < 0.0001): a high-risk group, characterized by the presence of B-symptoms [median overall survival (OS) of 2 months]; an intermediate-risk group, comprising patients without B-symptoms and an IPI score ≥ 2 (7 months); and a low-risk group, representing patients without B-symptoms and an IPI score of 0 to 1 (34 months). Internal validation showed stability of statistical significance and prognostic discrimination. In contrast with the IPI and PIT, the EPI better classified patients in risk groups according to their clinical outcome.
CONCLUSIONS:Our new, validated, prognostic model EPI accurately predicts survival outcome in EATL and may be used for patient selection for new therapeutic strategies and evaluation of clinical trials.

译文

目的: 肠病相关 T 细胞淋巴瘤 (EATL) 是一种罕见的肠道非霍奇金淋巴瘤,预后虽然多变,但很差。国际预后指数 (IPI) 和外周 T 细胞淋巴瘤预后指数 (PIT) 对 EATL 结果的预测价值有限。本研究的目的是开发和验证 EATL 的预后模型,该模型可以识别需要更积极治疗的高危患者。
实验设计: 这项回顾性多中心研究基于 92 名患者,包括 45 名 1999年和 2009 被诊断为 EATL 的荷兰患者和 47 名 1994年和 1998 被诊断为 EATL 的英格兰和苏格兰患者。使用 RPART (递归分区和回归树) 程序构建了一个新的 EATL 预后指数 (EPI)。应用 bootstrap 方法执行验证。
结果: 区分了三个风险组 (P <0.0001): 一个高风险组,其特征是存在 B 症状 [中位总生存期 (OS) 为 2 个月]; 一个中等风险组,包括无 B 症状且 IPI 评分 ≥ 2 分 (7 个月) 的患者; 和一个低风险组,代表无 B 症状的患者,IPI 评分为 0 至 1 (34 个月)。内部验证显示了统计学意义和预后区分的稳定性。与 IPI 和 PIT 相比,EPI 根据患者的临床结果更好地将患者分为风险组。
结论: 我们新的、经过验证的预后模型 EPI 准确预测了 EATL 的生存结果,可用于新治疗策略的患者选择和临床试验的评估。

Enteropathy-Associated T-cell Lymphoma

消化 结外淋巴瘤 疾病
概述  :  

肠病型T细胞淋巴瘤(enteropathy-associated T-cell lymphoma,EATL)是一种来源于上皮间T淋巴细胞的肿瘤,属于非霍奇金淋巴瘤的一个亚型,即结外淋巴瘤,该病最常发生在空肠、回肠,极少见于胃、十二指肠、结肠及消化道以外的部位,可呈节段性分布,表现为多灶性不规则溃疡。 病因及发病机制该病致病因素未完全阐明,目前认为和染色体异常、感染、免疫系统异常及其他理化学因素有关。 临床表现EATL最常见的临床表现为腹痛进行性加重,体重下降和难以控制的发

enteropathy  [,entə'rɒpəθɪ]

释义   n. 肠道病

例句   Diabetes enteropathy is diabetes one of many complications, the modern medicine still not was too at present clear to this sickness pathogenesis, also lacks the effective method in the treatment. 糖尿病肠病是糖尿病诸多并发症之一,现代医学对本病发病机制尚不太清楚,在治疗上也缺乏行之有效的方法。

 

associated  英[ə'səuʃi,eitid]  美 [əˈsoʊsieɪtɪd,əˈsoʊʃieɪtɪd]

释义   adj. 关联的;联合的

v. 联系(associate的过去式和过去分词)

例句   Ventilator-associated pneumonia(VAP)causes substantial morbidity. 呼吸机相关性肺炎(VAP)会引起重大的死亡率。

 

cell 英 [sel] 美 [sel]

释义   n. 细胞;电池;蜂房的巢室;单人小室

vi. 住在牢房或小室中

例句   You can move only one ball to any empty cell. 你只能移动一个球到任何空的单元格。

 

lymphoma 英 [lɪmˈfəʊmə] 美 [lɪmˈfoʊmə]

释义   n. [肿瘤] 淋巴瘤

复数 lymphomas或lymphomata

例句   The Leukemia & Lymphoma Society can also direct you to resources to assist you in talking with your children . 白血病及淋巴瘤协会也可以为你提供一些方法,帮助你和孩子进行交流。


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