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aortic stenosis

心血管

关键词心血管 疾病 主动脉

词汇介绍

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解析

Aortic 英 [eɪ'ɔːtɪk]  美 [e'ɔrtɪk] 

释    义   adj. 大动脉的

短    语   aortic dissection 主动脉夹层

aortic valve 主动脉瓣;织脉瓣


Stenosis 英 [stɪ'nəʊsɪs]  美 [stɪ'nosɪs] 

释    义   n. (器官)[病理] 狭窄

短    语   mitral stenosis 二尖瓣狭窄

pulmonary stenosis [医]肺动脉瓣狭窄

同根词   词根: stenosed

adj. stenosed 狭窄的;患狭窄症的  stenotic 狭窄的

例    句   To investigate the relationship between the length of the right coronary artery and coronary stenosis.

研究右冠状动脉的长度和其发生冠状动脉狭窄的关系。


概述

主动脉瓣狭窄(AS)最常见的病因是风湿性心脏病、先天性畸形、老年钙化性(退行性变),梗阻的部位可能在瓣膜、瓣膜上或瓣膜下。主动脉瓣狭窄时左心室向升主动脉射血时常会发生梗阻。风湿性炎症引起的单纯性主动脉瓣狭窄少见,大多伴有不同程度的主动脉关闭不全和二尖瓣狭窄。已诊断为此病的病人除无症状、病变较轻者外,多数需要手术治疗。出现充血性心力衰竭、晕厥和心绞痛等症状的病人自然生存期较短。病理生理正常成人主动脉瓣口面积3-4 cm2。主动脉瓣口面积减少至正常1/3前血流动力学改变不明显。当主动脉瓣口面积≤

Temporal Trends and Outcomes of Transcatheter Versus Surgical Aortic Valve Replacement for Bicuspid Aortic Valve Stenosis复制标题

经导管与外科主动脉瓣置换术治疗二叶式主动脉瓣狭窄的时间趋势和结果

发表时间:2019-09-23

影响因子:9.5

作者: Ayman Elbadawi

期刊:JACC Cardiovasc Interv

Transcatheter aortic valve replacement (TAVR) is indicated in patients with severe aortic stenosis (AS) who are deemed inoperable or are at intermediate or high surgical risk. Bicuspid aortic valve disease affects 1% to 2% of the U.S. population, and most of the affected patients require AVR at various ages. Bicuspid AS has been considered an anatomic challenge for TAVR procedures. Bicuspid AS has unique morphology compared with tricuspid AS,with large asymmetric heavily calcified leaflets, leading to a potential higher risk for paravalvular leakage or imprecise positioning during expansion of TAVR. Randomized trials have excluded bicuspid aortic valve morphology due to its unique anatomy that may negatively impact TAVR outcomes.

译文

经导管主动脉瓣置换术(TAVR)适用于患有严重主动脉瓣狭窄(AS)的患者,这些患者被认为无法手术或处于中等或高手术风险中。 二尖瓣主动脉瓣膜病影响美国人口的1%至2%,大多数受影响的患者在不同年龄段都需要AVR。 Bicuspid AS被认为是TAVR手术的解剖学挑战。 与三尖瓣AS相比,双尖瓣AS具有独特的形态,具有大的不对称重钙化小叶,导致TAVR扩张期间瓣周漏或定位不精确的潜在较高风险。 由于其独特的解剖结构可能会对TAVR结果产生负面影响,因此随机试验已排除了双尖瓣主动脉瓣形态。