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首页 > 医学词汇大全 > Transverse Aortic Constriction
Transverse Aortic Constriction

心血管

关键词心血管 实验技术 动物模型

词汇介绍

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解析

transverse 英 /trænz'vɜːs; trɑːnz-; -ns-/  美 /træns'vɝs/ 

释义   adj. 横向的;横断的;贯轴的  

n. 横断面;贯轴;横肌

例句   Transverse shear is due it that impact loading is not instantaneous. 由于冲击加载并不是瞬时的,这导致了横向剪切。

 

aortic 英 /eɪ'ɔːtɪk/  美 /e'ɔrtɪk/ 

释义   adj. 大动脉的

例句   Objective To investigate the application of continuous suture in aortic valve replacement. 目的探讨主动脉瓣置换中连续缝合方法的应用。

 

constriction 英 /kən'strɪkʃn/ 美 /kən'strɪkʃən/ 

释义   n. 收缩;压缩;紧窄感;压缩物

例句   Move finger smoothly toward nasal bridge; watch for pupil constriction and convergence. 手指平稳地向鼻柱移动,观察瞳孔收缩会聚情况。

概述

主动脉弓缩窄(Transverse Aortic Constriction,TAC)模型最早是由Rockman等首先建立并用于压力超负荷所致左室肥厚的研究,通常在无名动脉是一种典型的符合人类左心室肥厚的病理生理过程的动物模型。动物模型建立(1)麻醉:实验动物经腹腔注射氯胺酮/甲苯噻嗪麻醉;(2)气管插管:将实验动物仰卧位固定,镊子伸到喉部,撑开喉部,用改制套管针行气管插管,插管成功后接小动物呼吸机。(3)以胸骨左缘第2肋间隙为中心,剪毛、消毒、切开皮肤,精细镊子钝性分离肌肉组织。紧贴胸骨左缘

Distinct phenotypes Induced by three Degrees of transverse Aortic Constriction in Mice复制标题

小鼠主动脉横缩窄3度诱导的不同表型

发表时间:2019-04-10

影响因子:4.1

作者: Daniel A. Richards

期刊:SCI REP

Transverse aortic constriction (TAC) is one of the most common surgical models of pressure overload-induced cardiac hypertrophy and heart failure. In the TAC model a permanent constriction is placed around the transverse aorta, limiting left ventricular (LV) outflow and thereby creating pressure overload in the LV. TAC can produce profound adverse cardiac remodelling such as hypertrophy and fibrosis, as well as systolic and diastolic cardiac dysfunction and long-term progression to heart failure. The consistency of the constriction is maintained by using a blunt needle of fixed diameter alongside the aorta as a guide. The suture is tied tightly around the needle and the aorta, before the needle is removed, thus creating a permanent constriction. The degree of constriction “tightness” likely dictates the TAC severity and subsequent phenotype progression, since a small diameter needle would produce a more narrow constriction, whereas a larger diameter needle conversely would cause a milder constriction. The most commonly reported needle diameter for TAC is 27 gauge (27G), with a minority of studies using 25G, 26G or 28G. As such, few studies have directly compared the resulting phenotypes of different gauge TAC in great detail. Furthermore, the potentially different effects of varying degrees of pressure overload on LV haemodynamics, as well as on renal structure and function, remain unknown. This is particularly important since the selection of an informative model is critical to successful analysis of genetic or pharmacologic interventions in heart failure.

译文

横向主动脉缩窄(TAC)是压力超负荷引起的心脏肥大和心力衰竭的最常见手术模型之一。在TAC模型中,在横向主动脉周围放置永久性收缩,限制左心室(LV)流出,从而在LV中产生压力过载。 TAC可以产生严重的心脏不良重塑,例如肥大和纤维化,以及收缩和舒张性心脏功能障碍以及长期进展为心力衰竭。通过在主动脉旁边使用固定直径的钝针作为指导来维持收缩的一致性。在针被移除之前,缝合线紧紧地围绕针和主动脉,从而产生永久性收缩。收缩程度“紧密度”可能决定TAC严重程度和随后的表型进展,因为小直径针将产生更窄的收缩,而较大直径的针相反会导致较轻的收缩。 TAC最常报告的针头直径为27规格(27G),少数研究使用25G,26G或28G。因此,很少有研究直接比较不同规格TAC的最终表型。此外,不同程度的压力超负荷对LV血流动力学以及肾结构和功能的潜在不同影响仍然未知。这一点尤为重要,因为选择信息模型对于成功分析心力衰竭的遗传或药物干预至关重要。