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Baseline tumor oxygen saturation correlates with a pathologic complete response in breast cancer patients undergoing neoadjuvant chemotherapy.
基线肿瘤血氧饱和度与接受新辅助化疗的乳腺癌患者的病理完全缓解相关。

摘要

Tissue hemoglobin oxygen saturation (i.e., oxygenation) is a functional imaging endpoint that can reveal variations in tissue hypoxia, which may be predictive of pathologic response in subjects undergoing neoadjuvant chemotherapy. In this study, we used diffuse optical spectroscopic imaging (DOSI) to measure concentrations of oxyhemoglobin (ctO(2)Hb), deoxy-hemoglobin (ctHHb), total Hb (ctTHb = ctO(2)Hb + ctHHb), and oxygen saturation (stO(2) = ctO(2)Hb/ctTHb) in tumor and contralateral normal tissue from 41 patients with locally advanced primary breast cancer. Measurements were acquired before the start of neoadjuvant chemotherapy. Optically derived parameters were analyzed separately and in combination with clinical biomarkers to evaluate correlations with pathologic response. Discriminant analysis was conducted to determine the ability of optical and clinical biomarkers to classify subjects into response groups. Twelve (28.6%) of 42 tumors achieved pathologic complete response (pCR) and 30 (71.4%) were non-pCR. Tumor measurements in pCR subjects had higher stO(2) levels (median 77.8%) than those in non-pCR individuals (median 72.3%, P = 0.01). There were no significant differences in baseline ctO(2)Hb, ctHHb, and ctTHb between response groups. An optimal tumor oxygenation threshold of stO(2) = 76.7% was determined for pCR versus non-pCR (sensitivity = 75.0%, specificity = 73.3%). Multivariate discriminant analysis combining estrogen receptor staining and stO(2) further improved the classification of pCR versus non-pCR (sensitivity = 100%, specificity = 85.7%). These results show that elevated baseline tumor stO(2) are correlated with a pCR. Noninvasive DOSI scans combined with histopathology subtyping may aid in stratification of individual patients with breast cancer before neoadjuvant chemotherapy.

译文

组织血红蛋白氧饱和度 (即氧合) 是一种功能性成像终点,可以揭示组织缺氧的变化,这可能预测接受新辅助化疗的受试者的病理反应。在本研究中,我们使用漫射光学光谱成像 (DOSI) 来测量氧合血红蛋白 (ctO (2) Hb) 、脱氧血红蛋白 (ctHHb) 的浓度, 总 Hb (ctTHb = ctO (2) Hb ctHHb),氧饱和度 (stO (2) = ctO (2) Hb/ctTHb) 来自 41 名局部晚期原发性乳腺癌患者的肿瘤和对侧正常组织。测量是在新辅助化疗开始前获得的。分别分析光学衍生参数并与临床生物标志物结合,以评估与病理反应的相关性。进行判别分析以确定光学和临床生物标志物将受试者分为应答组的能力。42 个肿瘤中有 12 个 (28.6%) 获得了病理完全缓解 (pCR),30 个 (71.4%) 是非 pCR。PCR 受试者的肿瘤测量 stO (2) 水平 (中位数为 77.8%) 高于非 pCR 个体 (中位数为 72.3%,P = 0.01)。响应组之间的基线 ctO (2) Hb 、 ctHHb 和 ctTHb 没有显著差异。PCR 和非 pCR 确定了 stO (2) = 76.7% 的最佳肿瘤氧合阈值 (灵敏度 = 75.0%,特异性 = 73.3%)。结合雌激素受体染色和 stO (2) 的多变量判别分析进一步提高了 pCR 与非 pCR 的分类 (敏感性 = 100%,特异性 = 85.7%)。这些结果表明,升高的基线肿瘤 stO (2) 与 pCR 相关。无创 DOSI 扫描结合组织病理学分型可能有助于在新辅助化疗前对个体乳腺癌患者进行分层。

oxygen saturation

心血管 动脉血氧饱和度 临床研究术语
概述  :  

血红蛋白氧饱和度又简称血氧饱和度(SaO2),指Hb与氧结合的百分数,也即血液中氧合Hb占总Hb的百分数,约等于血氧含量与血氧容量的比值。正常动脉血氧饱和度(arterial oxygen saturation,SaO2)为95%~98%,静脉血氧饱和度(venous oxygen saturation,Sv02)为70%~75%。氧饱和度的大小主要取决于血氧分压的高低,两者的关系可用氧合血红蛋白解离曲线(简称氧解离曲线)表示,氧解离曲线呈S形。此外,血氧饱和度还与红细胞内2,3-二磷酸甘油

Oxygen 英 ['ɒksɪdʒ(ə)n]  美 ['ɑksɪdʒən] 

       n. [化学] 氧气,[化学] 氧

      oxygen content 氧含量,血氧含量

dissolved oxygen 溶解氧

同根词   n. oxygenation 以氧处理,氧化作用

vt. oxygenate 氧化,充氧;以氧处理;使…与氧化合  oxygenize 使氧化

       The burning of coal not only consumes oxygen in the house , but also

gives out poisonous gases.

煤燃烧的时候,不仅消耗房子里的氧气,而且还散发出有毒的气体。

 

Saturation 英 [sætʃə'reɪʃ(ə)n]  美 ['sætʃə'reʃən] 

       n. 饱和;色饱和度;浸透;磁化饱和

      water saturation 含水饱和度

saturation point 饱和点

同根词 (词根): saturate

adj. saturate 浸透的,饱和的;深颜色的  saturated 饱和的;渗透的;深颜色的

vt. saturate 浸透,使湿透;使饱和,使充满

       Adjust the opacity, saturation and brightness of windows based on when they last had focus. 

根据窗口上次聚焦的时间来调整其不透明度、饱和度和亮度。


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