释义 n. 戊脉安；异搏定（一种冠状动脉扩张药）
例句 To study the pharmacokinetics and pharmacodynamics of verapamil in patients with hypertension.
作者： David A Jackson
Hypoglycemia is the rate-limiting treatment barrier for people with insulin-treated diabetes. With an increased emphasis on glycemic control, the risk of severe hypoglycemia for insulin-treated patient rises markedly. Severe, life-threatening hypoglycemia occurs, on average, once per year for insulin-treated patients with diabetes. The increased morbidity resulting from severe hypoglycemia is mediated by brain glucose deprivation leading to seizures, coma, and brain damage. In clinical and pre-clinical studies, hypoglycemia-induced brain damage results in significant cognitive impairments characterized by deficits in spatial and orientation memory. Hypoglycemia induces a surge of stimulatory signals (excitotoxicity) leading to an inability of neurons to repolarize and control calcium influx. Excess calcium influx from the endoplasm reticulum and extracellular space initiates a positive feedback loop that leads to brain cell necrosis. Consistent with a major role of calcium influx in mediating other types of brain damage, treatment with the calcium channel blocker, verapamil, has been shown to reduce neural damage by up to 96% in other models of brain injury.