心血管
词汇介绍
拓展阅读
解析
释 义 adj. 长的;长时间的;远的;长音的;(人)高的;持续的;冗长的;记得牢的;较大量的;远期(获利)的
adv. 长期地;(某事之前或之后)很久地;(时间名词后)整个时间;远地
n. 长时间;长音;远期证券;(服装的)长尺寸;长裤
v. 渴望,盼望
同根词 adj. lengthy 漫长的,冗长的;啰唆的
longing 渴望的,极想得到的
adv. lengthwise 纵长地
例 句 Why do I have to stay in hospital so long?
我为什么要在医院里住这么长的时间?。
释 义 n. [临床] 综合症状;并发症状;校验子;并发位
n. (Syndrome)人名;(英)辛德罗姆
短 语 severe acute respiratory syndrome 严重急性呼吸系统综合症
irritable bowel syndrome [医]肠道易激综合症
nephrotic syndrome 肾病综合征
例 句 Women complain about premenstrual syndrome, but I think of it as the only time of the month that I can be myself.
女人会抱怨经前综合症,但是我认为这是一个月中我唯一可以能做回我自己的日子。
概述
Drug-induced fatal arrhythmias: Acquired long QT and Brugada syndromes复制标题
药物诱导的致死性心律失常: 获得性长QT和Brugada综合征
发表时间:2017-08-01
影响因子:9.4
作者: Isik Turker
期刊:Pharmacol. Ther.
Since the early 1990s, the concept of primary “inherited” arrhythmia syndromes or ion channelopathies has evolved rapidly as a result of revolutionary progresses made in molecular genetics. Alterations in genes coding for membrane proteins such as ion channels or their associated proteins responsible for the generation of cardiac action potentials (AP) have been shown to cause specific malfunctions which eventually lead to cardiac arrhythmias. These arrhythmic disorders include congenital long QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, short QT syndrome, progressive cardiac conduction disease, etc. Among these, long QT and Brugada syndromes are the most extensively studied, and drugs cause a phenocopy of these two diseases. To date, more than 10 different genes have been reported to be responsible for each syndrome. More recently, it was recognized that long QT syndrome can be latent, even in the presence of an unequivocally pathogenic mutation (silent mutation carrier). Co-existence of other pathological conditions in these silent mutation carriers may trigger a malignant form of ventricular arrhythmia, the so called torsade de pointes (TdP) that is most commonly brought about by drugs.
译文