心血管
词汇介绍
拓展阅读
解析
Endothelin
释义 内皮素
例句 The results suggest that endothelin promotes the development of brain edema and cerebral tissue damage.
结果表明脑外伤后内皮素促进了脑水肿的发生及脑组织的损伤。
概述
Tale of 2 Endothelin Receptor Antagonists in Eisenmenger Syndrome复制标题
2内皮素受体拮抗剂在艾森曼格综合征中的作用
发表时间:2019-01-02
影响因子:23.1
作者: Dunbar Ivy
期刊:Circulation
Endothelin is a potent vasoactive peptide discovered in 1988 by Yanagisawa et al. The effects of endothelin are mediated by Endothelin A (ETA) and Endothelin B (ETB) receptors. ETA receptors are located on vascular smooth muscle cells and mediate vasoconstriction. ETB receptors are on both endothelial cells and vascular smooth muscle cells. ETB receptors on endothelial cells may lead to the clearance of endothelin and production of nitric oxide, whereas ETB receptors on smooth muscle cells also mediate vasoconstriction. Several targeted therapies have been developed toward the endothelin receptors. In 2001, bosentan, a dual endothelin receptor antagonist, was approved by the US Food and Drug Administration as a treatment for group 1 PAH.
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