心血管
词汇介绍
拓展阅读
解析
Sick 英 [sɪk] 美 [sɪk]
释 义 n. 病人
adj. 厌恶的；病态的；不舒服；渴望的；恶心的
vt. 使狗去咬；呕吐；追击
n. (Sick)人名；(德、西)西克
同根词 adj. sickening 令人厌恶的；患病的
adv. sickly 病态地
n. sickness 疾病；呕吐；弊病
例 句 Why? I like my job because I want to make sick people better.
为什么？我喜欢我的工作，因为我想要病人好起来。
Sinus 英 ['saɪnəs] 美 ['saɪnəs]
释 义 n. [生物] 窦；静脉窦；下陷或凹下去的地方
短 语 maxillary sinus 上颌窦，上颌骨窦
sinus rhythm 窦性节律
cavernous sinus 海绵窦；海绵窦综合征
例 句 This normal variation in rhythm is known as sinus arrhythmia .
节律的这种正常变化称为窦性心律失常。
Syndrome 英 ['sɪndrəʊm] 美 ['sɪndrəm]
释 义 n. [临床] 综合症状；并发症状；校验子；并发位
n. (Syndrome)人名；(英)辛德罗姆
短 语 polycystic ovary syndrome 多囊卵巢综合征
chronic fatigue syndrome 慢性疲劳综合征；慢性疲劳症候群
respiratory distress syndrome 呼吸窘迫综合征
例 句 They said she had irritable bowel syndrome.
他们说她患有肠易激综合征。
概述
复制标题G蛋白门控IKACh通道作为治疗病态窦房结综合征和心脏传导阻滞的靶点
发表时间：2016-02-16
影响因子：9.6
作者： Pietro Mesirca
期刊：PNAS
The “sick sinus” syndrome (SSS) is characterized by abnormal formation and/or propagation of the cardiac impulse. SSS is responsible for about half of the total implantations of electronic pacemakers, which constitute the only currently available therapy for this disorder. We show that genetic ablation or pharmacological inhibition of the muscarinic-gated K+ channel (IKACh) prevents SSS and abolishes atrioventricular block in model mice without affecting the relative degree of heart rate regulation.We propose that “compensatory” genetic or pharmacological targeting of IKACh channels may constitute a new paradigm for restoring defects in the balance between inward and outward currents in pacemaker cells. Our study may thus open a new therapeutic perspective to manage dysfunction of formation and conduction of the cardiac impulse.
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