Sotalol 英 ['səutəlɔl]
释义 n. 索他洛尔；甲磺胺心定；心得怡（β-受体阻滞药）
例句 However, amiodarone is more effe ctive in maintenance of sinus rhythm than sotalol. The adverse reaction of amiod arone on heart is less severe than that of sotalol.
作者： Elyes Dahmane
期刊：Clin Transl Sci
Sotalol is a class III anti-arrhythmic drug indicated for the treatment of AF and atrial flutter. In AF treatment, sotalol is initiated at a dose of 80 mg b.i.d., with gradual titration to 240–320 mg/day as needed to maintain normal sinus rhythm. To reduce the risk of life-threatening arrhythmias, QTc monitoring must be performed at 2–4 hours after each dose until the drug has achieved steady-state concentrations ( 3 days given an elimination half-life of 12 hours). Previously, sotalol was only available as an oral formulation, but, recently, an intravenous formulation was developed as an alternative in patients who are unable to take oral medications. However, the approved intravenous product must be administered as a 5-hour infusion and it still requires that patients be hospitalized for a minimum of 3 days for initiation of therapy. Additionally, the cost of intravenous sotalol is significantly higher than the oral product at ~ $1,413.00 per dose.