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Sotalol

心血管

关键词心血管 药物 临床用药

词汇介绍

拓展阅读

解析

Sotalol 英  ['səutəlɔl]

释义   n. 索他洛尔;甲磺胺心定;心得怡(β-受体阻滞药)

例句   However, amiodarone is more effe ctive in maintenance of sinus rhythm than sotalol. The adverse reaction of amiod arone on heart is less severe than that of sotalol.

然而,胺碘酮在维持窦性心律方面比索他洛尔更有效。阿莫阿龙对心脏的不良反应较索他洛尔轻。


概述

索他洛尔(sotalol)在长期用药时具有良好的安全性,可作为预防心房颤动(左心室功能正常且无结构性心脏病,或伴有冠心病、瓣膜心脏病和左心室肥厚的心房颤动患者)复发的一线用药。对于室性心律失常、房性早搏、房性心动过速也有较好疗效,也可用于植入型心律转复除颤器(ICD)术后的长期辅助治疗。能降低心率和频率依赖性血流动力学功能,对每搏量、每博工作指数或每博张力时间指数无显著影响,也不增加左室舒张末压。给人体静脉注射索他洛尔后心率和心排血量下降,每搏量不变,左、右心室压力增加很小或不增加,作用维持

Clinical Pharmacology-Driven Translational Research to Optimize Bedside Therapeutics of Sotalol Therapy复制标题

临床药理学驱动的转化研究优化索他洛尔治疗的床边疗法

发表时间:2019-07-22

影响因子:4.0

作者: Elyes Dahmane

期刊:Clin Transl Sci

Sotalol is a class III anti-arrhythmic drug indicated for the treatment of AF and atrial flutter. In AF treatment, sotalol is initiated at a dose of 80 mg b.i.d., with gradual titration to 240–320 mg/day as needed to maintain normal sinus rhythm. To reduce the risk of life-threatening arrhythmias, QTc monitoring must be performed at 2–4 hours after each dose until the drug has achieved steady-state concentrations ( 3 days given an elimination half-life of 12 hours). Previously, sotalol was only available as an oral formulation, but, recently, an intravenous formulation was developed as an alternative in patients who are unable to take oral medications. However, the approved intravenous product must be administered as a 5-hour infusion and it still requires that patients be hospitalized for a minimum of 3 days for initiation of therapy. Additionally, the cost of intravenous sotalol is significantly higher than the oral product at ~ $1,413.00 per dose.

译文

索他洛尔是一种III类抗心律失常药物,用于治疗房颤和心房扑动。 在AF治疗中,索他洛尔以80mg b.i.d.的剂量开始,根据需要逐渐滴定至240-320mg /天以维持正常的窦性心律。 为了降低危及生命的心律失常的风险,必须在每次剂量后2-4小时进行QTc监测,直到药物达到稳态浓度(3天,消除半衰期为12小时)。 以前,索他洛尔仅作为口服制剂提供,但是,最近,开发了静脉注射制剂作为无法服用口服药物的患者的替代品。 然而,批准的静脉注射产品必须以5小时输注给药,并且仍然需要患者住院至少3天以开始治疗。 此外,静脉注射索他洛尔的成本显着高于口服产品,每剂量约为1,413.00美元。