释义 adj. 心脏的，心脏病的；（与）贲门（有关）的
例句 These are signs of cardiac arrest -- and this is the time to begin CPR.
释义 n. [化学] 钠（11号元素，符号 Na）
例句 Active cell can maintain the proper concentration of sodium in the body.
释义 n. 电视台；频道；途径；方式；通道；水渠；航道；海峡；河床；信道，（电子）沟道；输液管
例句 An engineer added an AM channel alongside the FM signal so that the station can be heard, onclear days, in places as far away as Europe.
作者： Babken Asatryan
期刊：J Clin Med
The alpha subunit of the cardiac voltage-gated sodium channel NaV1.5 (SCN5A), which is responsible for the rapid depolarization phase of the cardiac action potential, has been one of the first studied ion channels since the early days of cardiovascular genetic research. Unlike other cardiac-relevant genes that are typically implicated in either cardiac channelopathies or cardiomyopathies, rare variants in SCN5A have been associated with an incredibly diverse spectrum of frequently overlapping electrical and structural phenotypes. Loss-of-function variants have been linked to Brugada syndrome, progressive cardiac conduction disease (PCCD), congenital atrioventricular block, sick sinus syndrome, idiopathic ventricular fibrillation, and atrial standstill, while gain-of-function variants have been associated with long QT syndrome type 3, and multifocal ectopic Purkinje-related premature contractions (MEPPC). Other SCN5A-mediated conditions such as familial atrial fibrillation, sudden infant death syndrome, familial dilated cardiomyopathy (DCM), and, rarely, arrhythmogenic right ventricular cardiomyopathy (ARVC), have a more complex pathophysiology with involvement of multiple molecular phenotypes. A great variation of phenotypes has been noted even within the affected families and in individual patients over time, but to date, genotype–phenotype analyses have not been able to explain this variation in a clinical phenotype.