释 义 adj. 内质的
例 句 This may be merely due to enzyme in transit to lysosomes after synthesis on rough endoplasmic reticulum.
Reticulum 英 /rɪ'tɪkjʊləm/ 美 /rɪ'tɪkjələm/
释 义 n. 网状组织，网状质；网罟座（南天的星座）；[脊椎] 蜂巢胃
例 句 Major intrinsic protein The sarcoplasmic reticulum is a system of intracellular membranes.
释 义 n. 压力；强调；紧张；重要性；重读
例 句 The spokesman stressed that the measures did not amount to an overall ban.
作者： Luiz H.M. Bozi
期刊：Int. J. Cardiol
Taking into consideration that JNK activates the transcription factor FOXO3a [19, 26], we further tested whether JNK would upregulate BNIP3 in a FOXO3a-dependent manner. Of interest, ER stress reduced phosphorylation of FOXO3a at Ser253, with no change in total protein levels of FOXO3a (Figure 3A). At baseline, inhibition of JNK had no effect in both phosphorylation and protein levels of FOXO3a, however, under ER stress condition, inhibition of JNK increased protein levels of FOXO3a and prevented the reduction in phosphorylation of FOXO3a at Ser253 (Figure 3A). In control condition, siRNA mediated FOXO3a knockdown did not change gene expression and protein levels of BNIP3 (Figure 3B-D). However, siRNA-mediated FOXO3a knockdown prevented ER stress-induced increase in both gene expression and protein levels of BNIP3 (Figure 3B-D). In control condition, siRNA-mediated BNIP3 knockdown had no effect in protein levels of ER stress markers, cardiomyocyte contractility and Ca2+ transient (Fig. 3E-F; 4A-D). Interestingly, siRNA-mediated BNIP3 knockdown prevented ER stress-induced impaired cardiomyocyte shortening, maximal velocities of shortening and relengthening, and amplitude of Ca2+ transient (Fig. 4A-D).