首页 > 心血管医学词汇大全 > Heart failure with preserved ejection fraction
Increased Myocardial Stiffness in Patients With High-Risk Left Ventricular Hypertrophy: The Hallmark of Stage-B Heart Failure With Preserved Ejection Fraction.
高危左心室肥厚患者心肌僵硬度增加: 射血分数保留的 B 期心力衰竭的标志。
diastole heart failure hypertrophy, left ventricular vascular stiffness ventricular dysfunction, left
下载

摘要

BACKGROUND:Individuals with left ventricular hypertrophy (LVH) and elevated cardiac biomarkers in middle age are at high risk for the development of heart failure with preserved ejection fraction (HFpEF). However, it is unknown what the pathophysiological underpinnings of this high-risk state may be. We tested the hypothesis that patients with LVH and elevated cardiac biomarkers would demonstrate elevated left ventricular (LV) myocardial stiffness in comparison with healthy controls as a key marker for future HFpEF.
METHODS:Forty-six patients with LVH (LV septum >11 mm) and elevated cardiac biomarkers (N-terminal pro-B-type natriuretic peptide [>40 pg/mL] or troponin T [>0.6 pg/mL]) were recruited, along with 61 age- and sex-matched (by cohort) healthy controls. To define LV pressure-volume relationships, right heart catheterization and 3-dimensional echocardiography were performed while preload was manipulated using lower body negative pressure and rapid saline infusion.
RESULTS:There were significant differences in body size, blood pressure, and baseline pulmonary capillary wedge pressure between groups (eg, pulmonary capillary wedge pressure: LVH, 13.4±2.7 versus control, 11.7±1.7 mm Hg, P

译文

背景: 中年时左心室肥厚 (LVH) 和心脏生物标志物升高的个体是射血分数保留的心力衰竭 (HFpEF) 的高危人群。然而,尚不清楚这种高风险状态的病理生理学基础可能是什么。我们测试了这样一个假设,即与健康对照组相比,LVH 患者和心脏生物标志物升高的患者将显示出左心室 (LV) 心肌硬度升高,这是未来 HFpEF 的关键标志。
方法: 46 例 LVH 患者 (LV 隔膜> 11毫米) 和升高的心脏生物标记物 (N 末端 b型钠尿肽原 [> 40 pg/mL] 或肌钙蛋白 T [> 0.6 pg/mL]) 被招募, 以及 61 个年龄和性别匹配 (按队列) 的健康对照。为了确定 LV 压力-容量关系,在使用下体负压和快速生理盐水输注操作预负荷的同时,进行右心导管插入术和三维超声心动图检查。
结果: 两组在体型、血压和基线肺毛细血管楔压方面有显著差异 (例如,肺毛细血管楔压: LVH,13.4 ± 2)。 7 与对照组,11.7 ± 1。 7毫米汞柱,P

Heart failure with preserved ejection fraction

心血管 心脏功能障碍疾病 疾病
概述  :  

射血分数保留型心力衰竭(HFpEF)是一种临床综合征,患者有心衰的症状和体征,左心室射血分数(LVEF)正常或接近正常(即≥50%),且有证据表明心脏功能障碍(例如,左室充盈异常和充盈压升高)是其症状原因。以前将HFpEF称为舒张性心力衰竭。 病因典型的HFpEF通常与以下因素相关:收缩期高血压,无论是否伴有左心室肥厚;老龄;冠状动脉心脏病;糖尿病;睡眠呼吸障碍;肥胖;肾脏疾病。 病理生理学左心室在不升高肺静脉压的情况下能充分充盈需满足以下条件:适当的收缩期射血;能够通过

Heart failure

释义   inability of the heart to pump enough blood to sustain normal bodily functions 心力衰竭

例句   Acute heart failure is a clinical syndrome.

急性心力衰竭是一个临床综合征。

 

Preserved 英 /prɪ'zɜːvd/  美 /prɪ'zɝv/ 

释义   adj. 保留的,保藏的;腌制的;喝醉的

例句   The yolk sac and yolk stalk on one of them were well preserved.

其中1个卵黄囊和卵黄蒂保存完好。

 

ejection fraction

释义   射血分数

短语   Peak Velocity Ejection Fraction 峰值射血率;left ventriettlar ejection fraction 左室射血分数


请扫描右侧二维码,免费查看词汇专业知识背景