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首页 > 医学词汇大全 > Heart failure with preserved ejection fraction
Heart failure with preserved ejection fraction

心血管

关键词心血管 疾病 心脏功能障碍疾病

词汇介绍

拓展阅读

解析

Heart failure

释义   inability of the heart to pump enough blood to sustain normal bodily functions 心力衰竭

例句   Acute heart failure is a clinical syndrome.

急性心力衰竭是一个临床综合征。

 

Preserved 英 /prɪ'zɜːvd/  美 /prɪ'zɝv/ 

释义   adj. 保留的,保藏的;腌制的;喝醉的

例句   The yolk sac and yolk stalk on one of them were well preserved.

其中1个卵黄囊和卵黄蒂保存完好。

 

ejection fraction

释义   射血分数

短语   Peak Velocity Ejection Fraction 峰值射血率;left ventriettlar ejection fraction 左室射血分数


概述

射血分数保留型心力衰竭(HFpEF)是一种临床综合征,患者有心衰的症状和体征,左心室射血分数(LVEF)正常或接近正常(即≥50%),且有证据表明心脏功能障碍(例如,左室充盈异常和充盈压升高)是其症状原因。以前将HFpEF称为舒张性心力衰竭。 病因典型的HFpEF通常与以下因素相关:收缩期高血压,无论是否伴有左心室肥厚;老龄;冠状动脉心脏病;糖尿病;睡眠呼吸障碍;肥胖;肾脏疾病。 病理生理学左心室在不升高肺静脉压的情况下能充分充盈需满足以下条件:适当的收缩期射血;能够通过

Heart failure with preserved ejection fraction: from mechanisms to therapies复制标题

射血分数保留的心力衰竭: 从机制到治疗

发表时间:2018-08-01

影响因子:23.4

作者: Carolyn S P Lam

期刊:Eur. Heart J.

Heart failure with preserved ejection fraction (HFpEF) is a clinical syndrome in which patients have symptoms of HF, a left ventricular ejection fraction (LVEF) ≥50 percent, and evidence of cardiac dysfunction as a cause of symptoms (eg, abnormal LV filling and elevated filling pressures).  When diagnosing HFpEF, it is important to exclude mimics including non-HF conditions as well as other causes of HF with an LVEF ≥50 percent, such as valvular heart disease, pericardial disease, cardiomyopathies, cardiac amyloidosis, and high output HF. The major contributors to HFpEF are systemic hypertension, aging, coronary artery disease, diabetes and metabolic syndrome, obesity, and kidney disease. Occult coronary heart disease is a common and potentially reversible cause of HFpEF.  Plasma brain natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) may be elevated or normal in patients with HFpEF. Natriuretic peptide levels should be interpreted with attention to potential confounding factors including renal failure (which causes elevated BNP levels and even greater elevation in NT-proBNP levels), obesity (which tends to depress BNP and NT-proBNP levels), as well as conditions other than left-sided HF that cause elevations in levels.

译文

保留射血分数(HFpEF)的心力衰竭是一种临床综合症,其中患者有HF症状,左心室射血分数(LVEF)≥50%,并且心脏功能障碍的证据是症状的原因(例如,LV充盈异常和填充压力升高)。在诊断HFpEF时,重要的是排除包括非HF条件的模拟物以及LVEF≥50%的HF的其他原因,例如心脏瓣膜病,心包疾病,心肌病,心脏淀粉样变性和高输出HF。HFpEF的主要贡献者是系统性高血压,衰老,冠状动脉疾病,糖尿病和代谢综合征,肥胖和肾病。隐匿性冠心病是HFpEF的常见且可能可逆的原因。HFpEF患者的血浆脑利钠肽(BNP)和N末端proBNP(NT-proBNP)可能升高或正常。利钠肽水平应该注意潜在的混杂因素,包括肾功能衰竭(导致BNP水平升高,甚至NT-proBNP水平升高),肥胖(这往往会抑制BNP和NT-proBNP水平),以及条件除了左侧HF,导致水平升高。