首页 > 医学词汇大全 > Pulmonary arterial hypertension
Pulmonary arterial hypertension

心血管

关键词心血管 疾病 肺部疾病

词汇介绍

拓展阅读

解析

Pulmonary 英/'pʌlmən(ə)rɪ/ 美/'pʌlmənɛri/

释        义   adj. 肺的;有肺的;肺状的

同近义词   pneumonic adj. 肺的;有肺的;肺状的

例        句   Results: The cause of congenital pulmonary hypoplasia may be related with heredity and virus infection early on fetus.

结        果   先天性肺发育不全的原因可能与遗传、胚胎早期病毒感染等因素有关。

 

A rterial 英/ɑː'tɪərɪəl/ 美/ɑr'tɪrɪəl/

释        义   adj. [解剖] 动脉的;干线的;像动脉的

同  根  词   arteriosclerotic n. 动脉硬化的

Objective:To discuss the means and clinic value of transcatheter arterial embolization in traumatogenic hemorrhage.

目的:讨论经导管动脉栓塞治疗创伤性出血的方法和临床价值。

 

Hypertension 英/haɪpə'tenʃ(ə)n/ 美/,haɪpɚ'tɛnʃən/

释        义   a common disorder in which blood pressure remains abnormally high (a reading of 140/90 mm Hg or greater) n. 高血压;过度紧张

同  根  词   hypertrophy n.[病理] 肥大;过度增大;hypersomnia n.嗜睡,[医] 睡眠过度

例        句   Hypertension and high cholesterol can be controlled.

高血压和高胆固醇可以控制。

概述

定义肺高压的特征是肺动脉压升高(静息时平均肺动脉压≥25 mmHg)。根据WHO分类系统,肺高压分为5型。肺动脉高压(PAH)用于描述WHO 1型包含的患者,PAH病因包括:特发性和遗传性PAH;药物和毒物;结缔组织病;HIV;门静脉高压;先天性心脏病;血吸虫病。虽然男性和女性均可罹患PAH,但女性更可能受累(女性:男性的比值范围为1.7:1.0-4.8:1.0),女性也更可能出现PAH导致的症状。 临床表现劳力性胸痛(即,心绞痛)通常是由右心室壁应力和心肌需氧量增加所致的心

Ironing out pulmonary arterial hypertension复制标题

烫平肺动脉高压

发表时间:2019-06-06

影响因子:9.5

作者: Jodie L. Babitt

期刊:PNAS

The diagnosis is often delayed because the presenting features of PH are frequently attributed incorrectly to age, deconditioning, or a coexisting or alternate medical condition. As a result, PH is often not suspected until symptoms become severe or serious. It has been estimated that more than 20 percent of patients have symptoms of PH for longer than two years before it is recognized. Symptoms — Common symptoms include the following: Dyspnea and fatigue; Symptoms of right ventricular (RV) failure:Exertional chest pain,Exertional syncope,Weight gain from edema,Anorexia and/or abdominal pain and swelling. The diagnosis of PAH requires RHC to demonstrate an mPAP ≥20 mmHg at rest and a pulmonary vascular resistance (PVR) ≥3 Wood units. Several additional criteria to exclude the remaining categories of PH must also be met: Mean pulmonary capillary wedge pressure ≤15 mmHg (to exclude PH due to left heart disease [ie, group 2 PH]);CLDs and other causes of hypoxemia are mild or absent (to exclude PH owing to CLD or hypoxemia [ie, group 3 PH]);Venous thromboembolic disease and pulmonary artery obstructions are absent (to exclude group 4 PH);Certain miscellaneous disorders are absent, including systemic disorders (eg, sarcoidosis, chronic renal insufficiency), hematologic disorders (eg, myeloproliferative diseases and chronic hemolytic anemias), and metabolic disorders (eg, glycogen storage disease). The purpose is to exclude PH with unclear multifactorial mechanisms (group 5 PH).

译文

诊断经常被延迟,因为PH的呈现特征经常被错误地归因于年龄,去适应或共存或替代医学状况。因此,在症状严重或严重之前,通常不会怀疑PH。据估计,超过20%的患者在被识别之前有超过两年的PH症状。症状 - 常见症状包括:呼吸困难和疲劳;右心室(RV)衰竭的症状:劳累性胸痛,劳累性晕厥,水肿引起的体重增加,厌食和/或腹痛和肿胀。PAH的诊断要求RHC在休息时显示mPAP≥20mmHg,肺血管阻力(PVR)≥3Wood单位。还必须满足几个额外的标准,以排除剩余的PH类别:平均肺毛细血管楔压≤15mmHg(排除由于左心病引起的PH [即,第2组PH]); CLD和其他低氧血症的原因是轻微的或缺席(排除因CLD或低氧血症引起的PH [即第3组PH]);静脉血栓栓塞性疾病和肺动脉阻塞不存在(排除第4组PH);缺乏某些其他疾病,包括系统性疾病(如结节病,慢性肾功能不全),血液病(例如,骨髓增生性疾病和慢性溶血性贫血)和代谢紊乱(例如,糖原贮积病)。目的是排除具有不明确的多因素机制的PH(第5组PH)。