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calcium overload

心血管

关键词心血管 临床研究术语 Ca2+含量异常增多并导致细胞结构损伤和功能代谢障碍的现象

词汇介绍

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解析

Calcium 英 [ˈkælsiəm]  美 [ˈkælsiəm] 

释   义   n. [化学] 钙

短   语   calcium chloride 氯化钙

calcium phosphate n. [化]磷酸钙

例    句   Vitamin D helps the body absorb calcium and stimulates bone formation. 维生素D能帮助人体吸收钙,刺激骨骼形成。

 

Overload 英 [ˌəʊvəˈləʊd]  美 [ˌoʊvərˈloʊd] 

释   义   v.(使)过载,超载;(使)负担过重;(使)电力系统超负荷

n. 超载量

短   语   overload protection 防止过载,超载防护

information overload 信息过载;信息超载;信息超负荷

同根词   adj.overladen 过分的;装载过多的

例    句   Even at that rate, there is a risk of overload. 

哪怕是以这样的速度进行,仍存在超载的危险。

概述

再灌注损伤发生时,再灌注区细胞内Ca2+浓度迅速增高,且Ca2+浓度升高的程度往往与细胞受损的程度呈正相关。各种原因引起的细胞内Ca2+含量异常增多并导致细胞结构损伤和功能代谢障碍的现象,称为钙超载( calcium overload)。1966年 Zimmerman和Husmann发现了钙反常现象。用无Ca2+溶液灌注大鼠离体心脏,短时间内即发生肌膜损伤,随后灌注含Ca2+溶液后发现,心肌细胞中钙含量明显增加,且心脏发生更为严重的结构和功能改变。1986年 You

Examination of the Changes in Calcium Homeostasis in the Delayed Antiarrhythmic Effect of Sodium Nitrite复制标题

亚硝酸钠延迟抗心律失常作用中钙稳态变化的检测

发表时间:2019-11-03

影响因子:4.2

作者: Demeter-Haludka V

期刊:Int J Mol Sci

We have evidence that the intravenous infusion of sodium nitrite (NaNO) results in an antiarrhythmic effect when given 24 h prior to an ischemia and reperfusion (I/R) insult in anaesthetized dogs. This protection was associated with the reduction of reactive oxygen species resulting from I/R through the attenuation of mitochondrial respiration. Here, we examined whether the changes in calcium, which also contributes to arrhythmia generation, play a role in the NaNO-induced effect. On the first day, 30 anaesthetized dogs were treated either with saline or NaNO (0.2 µmol/kg/min) for 20 min. Some animals were subjected to a 25 min LAD (anterior descending branch of the left coronary artery) occlusion and 2 min reperfusion (I/R = 4; NaNO-I/R = 6), or the heart was removed 24 h later. We have shown that nitrite prevented the I/R-induced increase in cellular and mitochondrial calciumdeposits. During simulated I/R, the amplitude of the calcium transient and the diastolic calcium level were significantly lower in the nitrite-treated hearts and the ERP (effective refractory period) fraction of the action potential was significantly increased. Furthermore, nitrite also enhanced the mitochondrial respiratory response and prevented the MPTPT opening during calcium overload. These results suggest that nitrite can reduce the harmful consequences of calcium overload, perhaps directly by modulating ion channels or indirectly by reducing the mitochondrial ROS (reactive oxygen species) production.

译文

我们有证据表明,在麻醉犬的缺血和再灌注(I / R)损伤之前24小时给予亚硝酸钠(NaNO)静脉输注会产生抗心律不齐的作用。这种保护作用与通过减少线粒体呼吸作用而降低I / R引起的活性氧的含量有关。在这里,我们检查了钙的变化(也有助于心律失常的产生)是否在NaNO诱导的作用中起作用。 在第一天,用盐水或NaNO(0.2μmol/ kg / min)处理30只麻醉的狗20分钟。一些动物接受了25分钟的LAD(左冠状动脉的前降支)闭塞和2分钟的再灌注(I / R = 4; NaNO-I / R = 6),或者在24小时后取出心脏。我们已经表明,亚硝酸盐阻止了I / R诱导的细胞和线粒体钙沉积的增加。 在模拟I / R期间,亚硝酸盐治疗的心脏中钙瞬变幅度和舒张期钙水平明显降低,动作电位的ERP(有效不应期)分数显着增加。此外,亚硝酸盐还增强了线粒体的呼吸反应,并防止了钙超载期间MPTPT的开放。这些结果表明,亚硝酸盐可以减少钙超载的有害后果,可能直接通过调节离子通道或通过减少线粒体ROS(活性氧)的产生而间接减少。