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首页 > 医学词汇大全 > Hyperhomocysteinemia
Hyperhomocysteinemia

心血管

关键词心血管 疾病 血液中同型半胱氨酸水平升高

词汇介绍

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解析

Hyperhomocysteinemia

释义   n. 高同型半胱氨酸血症

例句   Effect of Hyperhomocysteinemia on Structure and Function of Peripheral Nerve in Rat has been proved. 高同型半胱氨酸血症对大鼠周围神经结构和功能的影响已被证明。


概述

同型半胱氨酸(Homocysteine,Hcy),是人体内蛋氨酸代谢产生的一种含巯基的氨基酸,通常以原形经肾脏排泄。当叶酸摄入不足时,人体内Hcy 的产生增加;当肾功能受损时,Hcy 排泄减少。因此不管是叶酸摄入不足,还是肾功能不全,都会导致血液中Hcy 水平升高,导致高同型半胱氨酸血症(HHcy)。HHcy是中风和心脏病事件的一个独立危险因素,并被认为是动脉粥样硬化、某些灾难性癌症、阿尔茨海默病的病因或其结果。 HHcy发生机制根据血清Hcy水平,HHcy分为轻、中、重,分别为1

Hydrogen Sulfide Ameliorates Homocysteine-Induced Cardiac Remodeling and Dysfunction.复制标题

硫化氢改善同型半胱氨酸诱导的心脏重构和功能障碍。

发表时间:2019-03-24

影响因子:3.2

作者: Sumit Kar

期刊:Front Physiol

Patients with diabetes, a methionine-rich meat diet, or certain genetic polymorphisms show elevated levels of homocysteine (Hcy), which is strongly associated with the development of cardiovascular disease including diabetic cardiomyopathy. However, reducing Hcy levels with folate shows no beneficial cardiac effects. We have previously shown that a hydrogen sulfide (H2S), a by-product of Hcy through transsulfuration by cystathionine beta synthase (CBS), donor mitigates Hcy-induced hypertrophy in cardiomyocytes. However, the in vivo cardiac effects of H2S in the context of hyperhomocysteinemia (HHcy) have not been studied. We tested the hypothesis that HHcy causes cardiac remodeling and dysfunction in vivo, which is ameliorated by H2S. Twelve-week-old male CBS+/− (a model of HHcy) and sibling CBS+/+ (WT) mice were treated with SG1002 (a slow release H2S donor) diet for 4 months. The left ventricle of CBS+/− mice showed increased expression of early remodeling signals c-Jun and c-Fos, increased interstitial collagen deposition, and increased cellular hypertrophy.

译文

患有糖尿病,富含蛋氨酸的肉食或某些遗传多态性的患者显示高半胱氨酸(Hcy)水平升高,这与心血管疾病(包括糖尿病性心肌病)的发展密切相关。但是,用叶酸降低Hcy水平不会显示有益的心脏作用。以前我们已经表明,硫化氢(H2S)是通过胱硫醚β合酶(CBS)进行转硫而产生的Hcy副产物,供体可减轻Hcy诱导的心肌肥大。但是,尚未研究高同型半胱氨酸血症(HHcy)背景下H2S的体内心脏作用。我们测试了HHcy在体内引起心脏重塑和功能障碍的假说,而H2S改善了这种假说。用SG1002(缓慢释放的H2S供体)饮食治疗十二周大的雄性CBS +/-(HHcy模型)和同胞CBS + / +(WT)小鼠4个月。CBS +/-小鼠的左心室显示早期重塑信号c-Jun和c-Fos的表达增加,间质胶原沉积增加和细胞肥大。值得注意的是,SG1002处理可稍微降低c-Jun和c-Fos表达,减少间质纤维化并减少细胞肥大