angiotensin 英 /,ændʒɪə(ʊ)'tensɪn/ 美 /,ændʒɪo'tɛnsən/
释义 n. 血管紧张肽；血管紧缩素
例句 ACE inhibitors work by blocking the action of a compound in the body called angiotensin converting enzyme.
receptor 英 /rɪ'septə/ 美 /rɪ'sɛptɚ/
释义 n. [生化] 受体；接受器；感觉器官
例句 This article reviewed the advancement in distribution, signal transduction and regulation mode of ETB receptor.
释义 n. 阻挡者；堵塞物；
例句 Objective To evaluate nimodipine, a calcium channel blocker, in the treatment of unstable bladder.
作者： Marie Evans
期刊：J. Am. Coll. Cardiol.
Chronic kidney disease (CKD) is an important risk factor for cardiovascular disease; the cardiovascular risk increases even with slightly decreased estimated glomerular filtration rate (eGFR) and becomes 8-fold higher in patients with severe renal dysfunction. Patients with CKD also have worse outcomes after an acute cardiovascular event compared with patients with normal renal function. Even though patients with low eGFR are considered a high risk group, the evidence for treating these patients with ACEI/ARB after MI is almost nonexistent as they were excluded from most trials. Importantly, ACEI or ARB use can also potentially result in acute kidney injury (AKI) and hyperkalemia, adverse events believed to be more common in CKD patients, perhaps discouraging clinicians from treating these patients with these agents. However, a recent observational study among U.S. veterans with CKD showed that use of an ACEI or ARB for any indication was associated with a 19% lower all-cause mortality. We aimed to investigate current use of ACEI and ARBtherapy after MI to assess long-term outcomes associated with their use in routine clinical practice across different risk profiles, including the entire spectrum of estimated glomerular function.